Sökning: "GABA channel"

Visar resultat 16 - 20 av 25 avhandlingar innehållade orden GABA channel.

  1. 16. Circadian rhythm dysfunction in the suprachiasmatic nucleus : effects of Trypanosoma brucei brucei infection and inflammatory cytokines

    Författare :Gabriella B Lundkvist; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Suprachiasmatic nucleus; slice; Trypanosoma brucei; sleeping sickness; spontaneous firing; rhytm; synaptic activity; GABA; glutamate; AMPA cytokines; sleep regulation; interferon-gamma; tumor necrosis factor-alpha;

    Sammanfattning : Alterations in the mammalian circadian pacemaker, the hypothalamic suprachiasmatic nuclei (SCN), were studied in an experimental rat model of African trypanosomiasis, or sleeping sickness, caused by infections with subspecies of Trypanosoma brucei (T b). Characteristic signs of the disease are marked disturbances in circadian rhythms, such as a fragmentation of the sleep-wake cycle. LÄS MER

  3. 17. Multiple neurotransmitter inputs modulate circadian clock neurons in Drosophila

    Författare :Yasutaka Hamasaka; Dick Nässel; François Rouyer; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; circadian; Drosophila; neurotransmitter; G-protein coupled receptor; Neurobiology; Neurobiologi;

    Sammanfattning : Most animals have endogenous circadian clocks, which drive daily rhythms in behavior and physiology to adapt to daily cycles of the environment. Several sets of neurons have been identified as circadian pacemakers (clocks) in the brain of Drosophila melanogaster, but the neuronal circuits and neurotransmitters signalling circadian information are poorly known. LÄS MER

  4. 18. Ion channels in drug discovery : focus on biological assays

    Författare :Kim Dekermendjian; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Ion channels; GABAA receptor; sodium channels; TRPM8; drug discovery; high throughput screening assays; FLIPR; automated electrophysiology;

    Sammanfattning : Ion channels are well characterised drug targets. However, the techniques used to study ion channel pharmacology have not been particularly applicable to modern drug discovery. LÄS MER

  5. 19. Ion homeostasis in control of stem cell proliferation

    Författare :Shaimaa Abdelhady; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The ion homeostasis is critically maintained in all cells by a combined effort from various ion channels, transporters, pumps, and gap junctions. Ion fluxes are essential in excitable cells as they regulate the excitability of the cells and initiate and propagate action potentials. LÄS MER

  7. 20. Host molecular determinants of toxoplasma gondii dissemination

    Författare :Jonas Fuks; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Humans and animals acquire the parasite Toxoplasma gondii through contaminated food or water, upon which the parasite rapidly disseminates in the host. In immunocompetent individuals, this acute phase is transient and leads to chronic colonization of preferentially the central nervous system (CNS). LÄS MER