Sökning: "G6pc"

Hittade 4 avhandlingar innehållade ordet G6pc.

  1. 1. Molecular mechanisms of antidiabetic effects of estrogen

    Författare :Galyna Bryzgalova; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Estrogen; glucose tolerance; insulin sensitivity; lipogenic genes; Lepr; Stat3; G6pc; Srebp1c;

    Sammanfattning : The role of estrogen in the development and regulation of female reproduction is well established. However, recent studies demonstrate that estrogen has a multiple effects on body functions. At present, it is becoming well recognized that one of the important roles of estrogen is the maintenance of glucose homeostasis. LÄS MER

  2. 2. Expression of the glucose-6-phosphatase system in endocrine cells

    Författare :Bee-Hoon Goh; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Glue os e- 6 -phphspatas e; G6PC; G6PT1; G6PC2; G6PC3; pancreatic islets; InR1G9 cells; GLUTag cells; glucagon producing a-cells; GLP-1 producing L-cells.;

    Sammanfattning : Glucose-6-phosphatase (G6pase) is a multi-component enzyme system, which regulates the catalysis of gluco se-6 -phosphate (G6P) to glucose and inorganic phosphate. This reaction constitutes the final steps of both gluconeogenesis and glycogenolysis, processes that are critical in the maintenance of glucose homeostasis. LÄS MER

  3. 3. Estrogen : molecular mechanisms of antidiabetic action

    Författare :Saad Misfer Al-Qahtani; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Sammanfattning : The pathogenesis of metabolic syndrome is multifactorial and hormones play an essential role in its development. Estrogen loss in postmenopausal women has been linked to several features of metabolic syndrome, while estrogen replacement therapy reverses these pathological and metabolic features. LÄS MER

  4. 4. Molecular mechanisms of estrogen action in relation to metabolic disease

    Författare :Lovisa Lundholm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Sammanfattning : p>Estrogens have multiple effects on the body. Most studied are the effects on female reproduction. In this thesis, we have focused on the metabolic effects of estrogens. Estrogen treatment decreases adipose tissue mass and has anti-diabetic effects in humans and mice. LÄS MER