Sökning: "G2-phase"

Visar resultat 6 - 10 av 14 avhandlingar innehållade ordet G2-phase.

  1. 6. Cell cycle regulation and DNA damage response : a record of polo-like kinase 1 activity

    Författare :Elvira Hukasova; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Division and cell proliferation is an essence of life. A human cell has in its core a very simple yet a very complex machinery to coordinate cell cycle activities and events. LÄS MER

  3. 7. Characterization of chromatin mobility upon DNA damage in Arabidopsis thaliana

    Författare :Anis Meschichi; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

    Sammanfattning : Plant cells are subject to high levels of DNA damage from dependence on sunlight for energy and the associated exposure to biotic and abiotic stresses. Double-strand breaks (DSBs) are a particularly deleterious type of DNA damage, potentially leading to chromosome rearrangements or loss of entire chromosome arms. LÄS MER

  4. 8. Intoxication of mammalian cells by the cytolethal distending toxin of Haemophilus ducreyi : a novel mechanism of action

    Författare :Ximena Cortes Bratti; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The cytolethal distending toxins (CDTs) are a newly described family of bacterial protein toxins with a novel mechanism of action: DNA damage. Haemophilus ducreyi produces a cytotoxin that belongs to this family. This bacterium causes chancroid, a sexually transmitted disease, characterised by mucocutaneous, slowly healing genital ulcers. LÄS MER

  5. 9. The use of IGF-IR inhibitors in cancer therapy : a potential approach for sensitizing tumor cells to ionizing radiation

    Författare :Daria Cosaceanu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : This study focused on insulin-like growth factor I receptor (IGF-IR), considered as a promising therapeutic target for cancer treatment. We were in particular interested in the involvement of IGF-IR in tumor cells response to radiation and we tried to provide the rationale for a combined therapy of IFG4R inhibitors with radiation in order to improve the therapeutic outcome. LÄS MER

  7. 10. Expression and regulation of Rad51 in human cells

    Författare :Jenny Flygare; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HsRad51 recombination; DNA repair; cell cycle; apoptosis; caspase-3; hybridization array;

    Sammanfattning : Double strand breaks (DSBs) can be caused by exogenous DNA damaging agents or by endogenous processes, and may lead to chromosomal breakage and rearrangement resulting in apoptosis or tumorigenesis. The repair of DSBs in higher eukaryotes is to a large extent accomplished by homologous recombination (HR), a process in which DNA from a complementary strand is used as a template for repair synthesis. LÄS MER