Sökning: "G-Protein-Coupled physiology"
Visar resultat 1 - 5 av 22 avhandlingar innehållade orden G-Protein-Coupled physiology.
1. Molecular simulations of G protein-coupled receptors : A journey into structure-based ligand design and receptor function
Sammanfattning : The superfamily of G protein-coupled receptors (GPCRs) contains a large number of important drug targets. These cell surface receptors recognize extracellular signaling molecules, which stimulates intracellular pathways that play major roles in human physiology. LÄS MER
2. Investigation on Pre- and Postsynaptic Ca2+ Signaling in Neuronal Model Systems
Sammanfattning : Communication between neuronal and non-neuronal is called volume transmission when the released neurotransmitter (NT) acts via diffusion and affects several target cells. Both the neurosecretory and postsynaptic cell responses are linked to [Ca2+]i elevations. LÄS MER
3. Free energy calculations of G protein-coupled receptor modulation : New methods and applications
Sammanfattning : G protein-coupled receptors (GPCRs) are membrane proteins that transduce the signals of extracellular ligands, such as hormones, neurotransmitters and metabolites, through an intracellular response via G proteins. They are abundant in human physiology and approximately 34% of the marketed drugs target a GPCR. LÄS MER
4. Signaling via Orexin Receptors : A Pharmacological Study
Sammanfattning : The orexin receptors are a pair of newly discovered G-protein coupled receptors which are activated by the neuropeptides orexins and play a role in sleep/vigilance, apetite/metabolism and neuroendocrine regulation. On a cellular level receptor activation results in, to name but a few effects, elevation of intracellular calcium and depolarisation. LÄS MER
5. The Role of Membrane Trafficking in G Protein-Coupled Receptor Regulation
Sammanfattning : Movements of a receptor in the plasma membrane and within the cell influence receptor function and physiology. I have investigated the role of such movements, generally known as membrane trafficking, in G protein-coupled receptor regulation. LÄS MER