Sökning: "G Protein-Coupled Receptor"

Visar resultat 16 - 20 av 168 avhandlingar innehållade orden G Protein-Coupled Receptor.

1. 16. The G-protein coupled receptor CMKLR1/ChemR23: Studies on gene regulation, receptor ligand activation, and HIV/SIV co-receptor function

   Författare :Ulrika Mårtensson; Drug Target Discovery; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; Medicine human and vertebrates ; HIV SIV; TIG2 chemerin; transcriptional regulation; ligand activation; Co-receptor; GPCR; ChemR23 CMKLR1;

   Sammanfattning : In all higher organisms, there is a need for intercellular communication. G-protein coupled receptors (GPCRs), located on the cell surface, play an important role in this communication. Cells synthesize and release signalling molecules (ligands), which produce a specific response only in those cells that have a receptor for that ligand. LÄS MER

3. 17. Expression and purification of membrane proteins: Focus on the G-protein coupled receptor MC4r

   Författare :Viveka Dolby; Biokemi och Strukturbiologi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; enzymology; Proteiner; enzymologi; Proteins; melanocortin 4 receptor; GPCR; purification; Expression; membrane proteins;

   Sammanfattning : Membrane proteins are crucial components of the cell and are involved in many biological processes. Recombinant overexpression systems together with different purification methods are necessary to obtain large amounts of purified receptor for biophysical and functional studies. LÄS MER

4. 18. The role of the G protein-coupled receptor ChemR23 in cardiovascular inflammation

   Författare :Gonzalo Artiach Castañón; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Cardiovascular inflammation is a biological process characterized by the immune cell response to harmful stimuli within the cardiovascular system, wherein homeostasis is reestablished by neutralizing the insult and promoting the repair of the damaged tissue. However, a failure in the resolution of inflammation can lead to a maladaptive inflammatory response, contributing to the development of cardiovascular diseases such as aortic valve stenosis (AVS) and atherosclerosis, as well as vascular complications such as intimal hyperplasia. LÄS MER

5. 19. Evolution of acetylcholine receptors and study of the anatomy of the mouse brain reward system

   Författare :Julia Pedersen; Dan Larhammar; Arnaud Chatonnet; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Ventral Tegmental Area; Mesocorticolimbic system; Glutamate; Optogenetics; Histology; Acetylcholine; Receptor; Muscarininc; Nicotinic; G protein-coupled receptor; Gene duplication; Tetraploidization; Synteny; Paralogon; Ohnolog; Zebrafish; Spotted gar; Neuroscience; Neurovetenskap;

   Sammanfattning : This thesis work is divided in two parts. In the first part, I make use of the transgenic TRPV1-Cre mouse line as a tool to investigate the midbrain ventral tegmental area (VTA). LÄS MER

7. 20. OX1 Orexin Receptor Signalling to Phospholipases

   Författare :Marie Ekholm; Jyrki Kukkonen; Graeme Milligan; Uppsala universitet; []
   Nyckelord :orexin; phospholipase; Calcium; cell signalling; G protein coupled receptor; ERK; live-cell imaging; arachidonic acid; diacylglycerol;

   Sammanfattning : The neuropeptides orexin-A and orexin-B were discovered in 1998 and were first described as regulators of feeding behaviour. Later research has shown that they have an important role in the regulation of sleep. Two G protein-coupled receptors, OX1 and OX2 orexin receptors, mediate the cellular responses to orexins. LÄS MER