Sökning: "Fysikalisk och oorganisk farmaceutisk kemi"

Visar resultat 1 - 5 av 9 avhandlingar innehållade orden Fysikalisk och oorganisk farmaceutisk kemi.

  1. 1. On Phase Behaviours in Lipid/Polymer/Solvent/Water Systems and their Application for Formation of Lipid/Polymer Composite Particles

    Författare :Anna Imberg; Per Hansson; Krister Thuresson; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Physical chemistry; Biodegradable; CLSM; Composite Particles; Controlled Release; Cubic Phases; Drug Delivery; Flory-Huggins Theory; FT-PGSE-NMR; IPMS; Liquid Phase; Lipid Domains; Liquid Handler; Microspheres; Microstructure; Phase Behaviour; Phase Separation; Polymer Matrix; SAXS; Segregation; Sponge Phase; Swelling; Fysikalisk kemi; Physical chemistry; Fysikalisk kemi; fysikalisk och oorganisk farmaceutisk kemi; Physical and Inorganic Pharmaceutical Chemistry;

    Sammanfattning : A new kind of lipid/polymer composite particle, consisting of a biodegradable polymer matrix with well-defined lipid domains, has been created. The lipid used is the water-swelling lipid monoolein (MO), which forms a reversed bicontinuous cubic diamond structure in aqueous solutions. LÄS MER

  3. 2. Characterisation of Aqueous Solutions, Liquid Crystals and Solid State of Non-ionic Polymers in Association with Amphiphiles and Drugs

    Författare :Annika Ridell; Martin Malmsten; Sven Engström; David Attwood; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Physical chemistry; polymer; surfactant; phase diagram; x-ray diffraction; fluorescence spectroscopy; calorimetry; PEG; cellulose ether; viscometry; cubic phase; liquid crystals; drugs; solid dispersion; Fysikalisk kemi; Physical chemistry; Fysikalisk kemi; Fysikalisk och oorganisk farmaceutisk kemi; Physical and Inorganic Pharmaceutical Chemistry;

    Sammanfattning : Cellulose ethers and polyethylene glycols are used in drug formulations as water swelling or water soluble matrices. Polar lipids, for example monoglycerides, and surfactants can be used to solubilise hydrophobic or amphiphilic drugs and to formulate potential drug delivery vehicles such as emulsions, liposomes and cubic phases. LÄS MER

  4. 3. Molecular dynamics and aggregation behaviour in aqueous polymer-drug model systems

    Författare :Hans Evertsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi; Physical and Inorganic Pharmaceutical Chemistry; fysikalisk och oorganisk farmaceutisk kemi;

    Sammanfattning : Pharmaceutical formulations often contain polymers used as binders, swelling agents, etc., to give the formulation mechanical stability or specific drug release features. Many drug substances, as well as polymers, are amphiphilic which will give an associative polymer-drug interaction, affecting the dissolution rate and drug release. LÄS MER

  5. 4. Effects of polyelectrolyte conformation, charge density and ion specificity in polyelectrolyte and polyelectrolyte-drug interaction

    Författare :Andreas M. Hugerth; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi; Physical and Inorganic Pharmaceutical Chemistry; fysikalisk och oorganisk farmaceutisk kemi;

    Sammanfattning : The central theme is how the structural characteristics of sulphated polyelectrolytes and theirinteraction with counter- and coions determine the degree of polyelectrolyte self-association (gelformation), interaction with oppositely charged polyelectrolyte and polyelectrolyte-amphiphilic druginteraction in protolytic solvent medium. Such knowledge is essential for understanding and regulatingthe interaction between polyelectrolytes as well as between polyelectrolytes and a drug substance in apharmaceutical formulation and for its fate in the human organism. LÄS MER

  7. 5. Electrolyte structures and ionization conditions for iontophoretic drug formulation of local anesthetics

    Författare :Kiomars Karami; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi; Physical and Inorganic Pharmaceutical Chemistry; fysikalisk och oorganisk farmaceutisk kemi;

    Sammanfattning : Iontophoresis is a modern method of drug delivery by which charged bioactive molecules (drugs) are transferred from an electrolytic reservoir into and through a tissue, normally skin, by means of a weak electric current. The drug is placed in a conductive medium, usually an aqueous solution or a hydrogel, between the "active" electrode and the skin. LÄS MER