Sökning: "Fushun Yu"

Hittade 1 avhandling innehållade orden Fushun Yu.

1. 1. Adaptability of skeletal muscle to hormone treatment in relation to gender and aging

   Författare :Fushun Yu; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :skinned muscle fiber; gender; aging; steroid hormone; V0 electrophoresis; MyHC; MyLC; enzymehistochemistry; hyperthyroid rat; thyroid hormone receptor TR deficient TR[alpha]1 - -; TR[beta]- -; and TR[alpha]1- -[beta]- - mice;

   Sammanfattning : The aims of this study were to investigate the expression of myosin isoforms, muscle contractility at the cell level, and changes in these parameters in response to altered hormonal status in aging male and female rodents. In addition, by using mice lacking thyroid hormone receptors (TR[alpha]1 or TR[beta] or TR[alpha]1/[beta]) we tried to improve our understanding of the mechanisms by which thyroid hormone regulates the expression of specific MyHC isoforms via these different nuclear receptors. LÄS MER