Sökning: "Functional genomics"
Visar resultat 6 - 10 av 116 avhandlingar innehållade orden Functional genomics.
6. Functional Genomics of Bone Metabolism : Novel Candidate Genes Identified by Studies in Chicken Models
Sammanfattning : Osteoporosis is a disease that leads to decreased bone mineral density (BMD), an altered bone micro-architecture and fragile bones. The disease is highly heritable and numerous genes are thought to be involved, making it difficult to identify the causative genetic elements. LÄS MER
7. Studies of Intracellular Transport and Anticancer Drug Action by Functional Genomics in Yeast
Sammanfattning : This thesis describes the use of functional genomics screens in yeast to study anticancer drug action and intracellular transport. The yeast Saccharomyces cerevisiae provides a particularly useful model system for global drug screens, due to the availability of knockout mutants for all yeast genes. LÄS MER
8. Functional genomics of vascular endothelial cells
Sammanfattning : Angiogenesis, the formation of new blood vessels from preexisting ones, is a process involved in normal development as well as in several pathological conditions, such as cancer, ischemic heart disease, wound healing and certain retinal complications. Antiangiogenic targeting is therefore a promising new therapeutic principle. LÄS MER
9. Functional genomics approaches to dissect causal DNA variations in obesity and type 2 diabetes
Sammanfattning : GWAS studies have identified hundreds of loci that associate with obesity and type 2 diabetes. However, the functional relevance of the genetic variants, and their impact on disease or traits, is largely unknown. LÄS MER
10. Inference of functional association networks and gene orthology
Sammanfattning : Most proteomics and genomics experiments are performed on a small set of well-studied model organisms and their results are generalized to other species. This is possible because all species are evolutionarily related. When transferring information across species, orthologs are the most likely candidates for functional equivalence. LÄS MER