Avancerad sökning

Visar resultat 1 - 5 av 544 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Functional association networks for disease gene prediction

   Författare :Dimitri Guala; Erik L L Sonnhammer; Hjalmar Brismar; Yves Moreau; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; network biology; biological networks; network prediction; functional association; functional coupling; network integration; functional association networks; genome-wide association networks; gene networks; protein networks; fret; functional enrichment analysis; network cross-talk; pathway annotation; gene prioritisation; network-based gene prioritization; benchmarking; Biochemistry towards Bioinformatics; biokemi med inriktning mot bioinformatik;

   Sammanfattning : Mapping of the human genome has been instrumental in understanding diseasescaused by changes in single genes. However, disease mechanisms involvingmultiple genes have proven to be much more elusive. Their complexityemerges from interactions of intracellular molecules and makes them immuneto the traditional reductionist approach. LÄS MER

3. 2. On the Relative Order of Adverbs in the I-domain: A study of English and Swedish

   Författare :Fabian Beijer; Engelska; []
   Nyckelord :HUMANIORA; HUMANITIES; Relativized Minimality; Starke 2001 ; Cinque 1999 ; Minimalist Program; PAROLE; BNC; functional sequence; functional projection; functional head; hierarchical order; Swedish; English; I-domain; AdvP; adverb phrase; adverb; adverbial; syntactic features; word order; merge; English language and literature; Engelska språk och litteratur ;

   Sammanfattning : This dissertation is a theoretical and empirical investigation of the ordering of adverbs in the I-domain. Within the generative-minimalist framework, adverbs have traditionally been analysed as adjuncts, adjoined to the syntactic structure in semantically appropriate positions (e.g. Jackendoff 1972). LÄS MER

4. 3. Functional Inference from Orthology and Domain Architecture

   Författare :Mateusz Kaduk; Erik Sonnhammer; Erich Bornberg-Bauer; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Orthology; Functional coupling networks; Association networks; Hierarchical groups of orthologs; Biochemistry towards Bioinformatics; biokemi med inriktning mot bioinformatik;

   Sammanfattning : Proteins are the basic building blocks of all living organisms. They play a central role in determining the structure of living beings and are required for essential chemical reactions. One of the main challenges in bioinformatics is to characterize the function of all proteins. LÄS MER

5. 4. Functional EDSLs for Web Applications

   Författare :Anton Ekblad; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; functional programming; domain-specific programming languages; distributed systems; web applications; tierless programming languages;

   Sammanfattning : This thesis aims to make the development of complex web applications easier, faster and safer through the application of strongly typed functional programming techniques. Traditional web applications are commonly written in the de facto standard language of the web, JavaScript, which, being untyped, provides no guarantees regarding the data processed by programs, increasing the burden of testing and defensive programming. LÄS MER

7. 5. THE ANDROGEN RECEPTOR GGN POLYMORPHISM. Genetic and functional analyses

   Författare :Kristina Lundin; Avdelningen för klinisk genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine human and vertebrates ; Functional domain; Genetic predisposition; Reproductive function; Sex hormone; Transactivation function; Repeat; Polymorphism; Androgen receptor; Transcription factor; Medicin människa och djur ; Endocrinology; secreting systems; diabetology; Endokrinologi; sekretion; diabetologi;

   Sammanfattning : Male sex development and reproductive function is regulated by androgens acting via the androgen receptor (AR). The AR harbours two polymorphic repeats of CAG and GGN triplets, encoding glutamines and glycines, respectively. LÄS MER