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Visar resultat 1 - 5 av 17 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Evaluation of fucosylated receptors for Cholera toxin in the human small intestine

    Författare :Jakob Cervin; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cholera toxin; Lewis antigen; HBGA; HMO; Fucose; GM1;

    Sammanfattning : Cholera toxin (CT) produced by Vibrio cholerae is the causative agent for the diarrheal disease cholera. Cholera is yearly afflicting millions and is estimated to kill over 100 000 people every year. In this thesis I aimed to better understand the role of noncanonical CT receptors, e.g. LÄS MER

  3. 2. Clinical studies on α1-acid glycoprotein glycosylation - with focus on fucose

    Författare :Ingvar Rydén; Joyce Carlson; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : α1-Acid glycoprotein (AGP, orosomucoid) is a heavily glycosylated protein found in blood plasma in all humans. AGP is one of the major acute phase proteins, and its concentration is frequently measured in clinical laboratories as a marker for inflammatory disease. LÄS MER

  4. 3. Studies on the biosynthesis of ABH and Lewis epitopes on O-glycans

    Författare :Jonas Löfling; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Fucose; Lewis antigen; Blood group ABH; biosynthesis;

    Sammanfattning : ABH and Lewis antigens are carbohydrate epitopes (glycans) found on a wide variety of cell surfaces. They are involved in many biological processes, e.g transplantation rejection, bacterial and viral adhesion, cell-cell communication and metastasis. The in vivo synthesis of glycans is mediated by glycosyltransferases (GTs). LÄS MER

  5. 4. Studies of recombinant forms of Aleuria aurantia lectin

    Författare :Johan Olausson; Peter Påhlsson; Peter Konradsson; Anders Larsson; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Molecular biology; Molekylärbiologi;

    Sammanfattning : The presented work describes construction and analysis of recombinantly produced forms of Aleuria aurantia lectin (AAL). The binding properties of the produced AAL forms were studied using techniques such as tryptophan fluorescence, hemagglutination analysis, ELISA and surface plasmon resonance analysis. LÄS MER

  7. 5. Synthesis of complex carbohydrates corresponding to the Lewis b blood group antigen and Vibrio cholerae polysaccharide structures

    Författare :Dominika Turek; Ulf Nilsson; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic Chemistry; organisk kemi;

    Sammanfattning : This thesis is divided into two parts. The first part describes the syntheses of the Lewis b blood group antigen hexasaccharide and parts thereof. The Leb blood group antigen is one of the binding epitopes for the Helicobacter pylori bacteria in the human stomach. LÄS MER