Sökning: "Free-Electron Lasers"

Visar resultat 11 - 15 av 40 avhandlingar innehållade orden Free-Electron Lasers.

1. 11. Coherent Diffractive Imaging with X-ray Lasers

   Författare :Max Felix Hantke; Filipe R. N. C. Maia; Janos Hajdu; Martin Svenda; Edgar Weckert; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; coherent diffractive X-ray imaging; lensless imaging; coherent X-ray diffractive imaging; flash diffractive imaging; single particle imaging; aerosol injection; electrospray injection; substrate-free sample delivery; carboxysome; phase retrieval; X-ray diffraction software; X-ray free-electron laser; XFEL; FEL; CXI; CDI; CXDI; FXI;

   Sammanfattning : The newly emerging technology of X-ray free-electron lasers (XFELs) has the potential to revolutionise molecular imaging. XFELs generate very intense X-ray pulses and predictions suggest that they may be used for structure determination to atomic resolution even for single molecules. LÄS MER

3. 12. Flash Diffractive Imaging in Three Dimensions

   Författare :Tomas Ekeberg; Janos Hajdu; Keith Nugent; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; X-ray; diffraction; mimivirus; three dimensional; phase retrieval; EMC; manifold embedding; CXI; FEL; free-electron laser; single particle; Physics with specialization in Biophysics; Fysik med inriktning mot biofysik;

   Sammanfattning : During the last years we have seen the birth of free-electron lasers, a new type of light source ten billion times brighter than syncrotrons and able to produce pulses only a few femtoseconds long. One of the main motivations for building these multi-million dollar machines was the prospect of imaging biological samples such as proteins and viruses in 3D without the need for crystallization or staining. LÄS MER

4. 13. Interaction of Ultrashort X-ray Pulses with Material

   Författare :Magnus Bergh; Janos Hajdu; Andrea Cavalleri; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; free-electron laser; dense plasma; X-ray; radiation damage; laser physics; nano-plasma; Molecular Dynamics; Molecular biophysics; Molekylär biofysik;

   Sammanfattning : Radiation damage limits the resolution in imaging experiments. Damage is caused by energy deposited into the sample during exposure. Ultrashort and extremely bright X-ray pulses from free-electron lasers (FELs) offer the possibility to outrun key damage processes, and temporarily improve radiation tolerance. LÄS MER

5. 14. Statistical processing of Flash X-ray Imaging of protein complexes

   Författare :Alberto Pietrini; Carl Nettelblad; Johan Bielecki; Janos Hajdu; Flavio Capotondi; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; X-ray; XFEL; single particle; hit-finder; statistical hit-finder; single protein; protein complex; RNA polymerase II; FEL; free-electron laser; FXI; Flash X-ray Imaging; CXI; CSPAD; x-ray imaging; COACS; Physics with specialization in Biophysics; Fysik med inriktning mot biofysik;

   Sammanfattning : Flash X-ray Imaging (FXI) at X-ray Free Electron Lasers (XFELs) is a promising technique that permits the investigation of the 3D structure of molecules without the need for crystallization, by diffracting on single individual sample particles.In the past few years, some success has been achieved by using FXI on quite large biological complexes (40 nm-1 μm in diameter size). LÄS MER

7. 15. From Solution into Vacuum - Structural Transitions in Proteins

   Författare :Alexandra Patriksson; David van der Spoel; Carol Robinson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; molecular dynamics; computer simulations; mass spectrometry; electrospray ionization; free-electron laser; vacuum structure of proteins; solvation; desolvation; single molecule imaging; Chemistry; Kemi;

   Sammanfattning : Information about protein structures is important in many areas of life sciences, including structure-based drug design. Gas phase methods, like electrospray ionization and mass spectrometry are powerful tools for the analysis of molecular interactions and conformational changes which complement existing solution phase methods. LÄS MER