Sökning: "Fredrik Palm"
Visar resultat 11 - 15 av 18 avhandlingar innehållade orden Fredrik Palm.
11. The role of hypoxia for the development of diabetic nephropathy : Temporal relationship and involvement of endothelin receptor signaling
Sammanfattning : Diabetic nephropathy is one of the most common causes of end stage renal disease and develops in approximately one third of all diabetes patients. Disease progression is characterized by deteriorating glomerular filtration rate and escalating urinary albumin/protein excretion; both are used as clinical markers for disease progression. LÄS MER
12. The Role of Mitochondrial Uncoupling in the Development of Diabetic Nephropathy
Sammanfattning : Diabetes is closely associated with increased oxidative stress, especially originating from the mitochondria. A mechanism to reduce increased mitochondria superoxide production is to reduce the mitochondria membrane potential by releasing protons across the mitochondria membrane. LÄS MER
13. Intrarenal oxygen homeostasis in acute and chronic kidney disease
Sammanfattning : Renal hypoxia has been recognized as a common feature of acute and chronic kidney injury arising from varying etiologies. It has also been proposed to provide a driving mechanism for the transition from acute to chronic kidney disease (CKD). LÄS MER
14. Studies on the Role of Apoptosis in Kidney Diseases
Sammanfattning : Apoptosis is one of the most common types of cell death. Under physiological conditions, it plays an essential role in removal of damaged and potentially harmful cells. Excessive apoptosis has however been linked to a number of diseases including proteinuric kidney disease and DKD, and is believed to enhance the disease progression. LÄS MER
15. Aspects of Regulation of GFR and Tubular Function in the Diabetic Kidney : Roles of Adenosine, Nitric Oxide and Oxidative Stress
Sammanfattning : Diabetic nephropathy is the main cause for initiation of renal replacement therapy and early symptoms in patients include increased glomerular filtration rate (GFR), decreased oxygen tension and albuminuria, followed by a progressive decline in GFR and loss of kidney function. Experimental models of diabetes display increased GFR, decreased tissue oxygenation and nitric oxide bioavailability. LÄS MER