Sökning: "Fredrik C. Kugelberg"

Hittade 4 avhandlingar innehållade orden Fredrik C. Kugelberg.

  1. 1. Chiral and toxicological aspects of citalopram : an experimental study in rats

    Författare :Fredrik C. Kugelberg; Olav Spigset; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Citalopram (CIT) is a selective serotonin reuptake inhibitor (SSRI), which is used for the treatment of different psychiatric disorders. The indications for prescription of OT are linked to high risks for intentional intoxications. CIT is one of the most commonly found drugs in Swedish forensic autopsy cases. LÄS MER

  3. 2. P-glycoprotein and chiral antidepressant drugs : Pharmacokinetic, pharmacogenetic and toxicological aspects

    Författare :Louise Karlsson; Fredrik C. Kugelberg; Finn Bengtsson; Johan Ahlner; Aleksander A. Mathé; Linköpings universitet; []
    Nyckelord :;

    Sammanfattning : The blood-brain barrier (BBB) is formed by the capillary endothelial cells, joined together by tight junctions, with transporter proteins. BBB acts to regulate the brain concentrations of substances including many drugs. LÄS MER

  4. 3. Zopiclone degradation in biological samples : Characteristics and consequences in forensic toxicology

    Författare :Gunnel Nilsson; Robert Kronstrand; Fredrik C. Kugelberg; Johan Ahlner; Mikael Hedeland; Linköpings universitet; []
    Nyckelord :;

    Sammanfattning : Bio-analytical results are influenced by in vivo factors such as genetics, pharmacological and physiological conditions and in vitro factors such as specimen composition, sample additives and storage conditions. Zopiclone (ZOP) is a short-acting hypnotic drug (Imovane®) used for treatment of insomnia. LÄS MER

  5. 4. Stability of zopiclone in whole blood : Studies from a forensic perspective

    Författare :Gunnel Nilsson; Robert Kronstrand; Johan Ahlner; Fredrik Kugelberg; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Bio‐analytical results are influenced by in vivo factors like genetic, pharmacological and physiological conditions and in vitro factors like specimen composition, sample additives and storage conditions. The knowledge of stability of a drug and its major metabolites in biological matrices is very important in forensic cases for the interpretation of analytical results. LÄS MER