Sökning: "Francisella tularensis Umeå Universitet"

Visar resultat 1 - 5 av 22 avhandlingar innehållade orden Francisella tularensis Umeå Universitet.

1. 1. The oxidative stress response of Francisella tularensis

   Författare :Marie Honn; Anders Sjöstedt; Helena Lindgren; Andres Melendez; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Francisella tularensis; FupA; MglA; OxyR; ROS; oxidative stress; molekylärbiologi; Molecular Biology;

   Sammanfattning : Francisella tularensis is capable of infecting numerous cell types, including professional phagocytes. Upon phagocytosis, F. tularensis resides within the phagosome before escaping into the cytosol to replicate. Phagocytes constitute a hostile environment rich in ROS, which are employed as a means of killing pathogens. LÄS MER

3. 2. Cutaneous resistance against Francisella tularensis

   Författare :Stephan Stenmark; Mikael Rhen; Umeå universitet; []
   Nyckelord :tularemia; Francisella tularensis; skin; protection; cytokines; T-cells; B-cells; specific antibodies; Infectious Diseases; infektionssjukdomar;

   Sammanfattning : Francisella tularensis, the causative agent of tularemia, is a potent pathogen in humans and other mammals. The ulceroglandular form of the disease is the most common expression in humans with a clinical picture characterized by a skin ulcer, enlarged regional lymph nodes and fever. LÄS MER

4. 3. Mechanisms of the intracellular survival of Francisella tularensis

   Författare :Linda Tancred; Anders Sjöstedt; Jean Celli; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Francisella tularensis; Igl; MglA; J774; IFN-γ; RNS; ROS; phagosome; Clinical bacteriology; Klinisk bakteriologi; mikrobiologi; Microbiology;

   Sammanfattning : Francisella tularensis is a gram-negative, highly virulent, intracellular bacterium which causes the zoonotic disease tularemia. The subspecies tularensis and holarctica are clinically important, and the former is the more virulent. The intracellular lifestyle of F. LÄS MER

5. 4. Characterization of the attenuated Francisella tularensis strain FSC043 : with special focus on the gene pdpC

   Författare :Marie Lindgren; Anders Sjöstedt; Marina Santic; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Francisella tularensis; intracellular bacteria; J774; apoptosis; pyroptosis; PdpC; FSC043; Clinical Bacteriology; klinisk bakteriologi; mikrobiologi; Microbiology;

   Sammanfattning : Francisella tularensis is a highly infective, intracellular bacterium. It is capable of infecting a wide range of mammals and causes the disease tularemia in humans. As a result of its high infectivity there have been a lot of efforts made to create a generally available vaccine against this pathogen. LÄS MER

7. 5. Francisella tularensis: persistence, dissemination and source attribution : a theoretical and computational approach

   Författare :Chinmay Kumar Dwibedi; Anders Johansson; Pär Larsson; Markus Antwerpen; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Francisella; genomics; evolution; microbial forensics; dispersal; persistence; mikrobiologi; Microbiology;

   Sammanfattning : The bacterium Francisella tularensis causing tularemia in humans and other mammals displays little genetic diversity among genomes across temporal and spatial scales. F. tularensis infects humans with an extremely low infectious dose and causes natural seasonal tularemia outbreaks. LÄS MER