Sökning: "Foxs1"
Hittade 5 avhandlingar innehållade ordet Foxs1.
1. Functional studies of two forkhead genes
Sammanfattning : Forkhead genes are functionally diverse and several have been linked to human disease. A previous screen for forkhead genes identified the family member FOXS1. To characterize the function of this gene, we produced a mouse model in which the Foxs1 gene was replaced by a lacZ marker allele. LÄS MER
2. GLI1 modulation of the output of hedgehog signaling in human cancer
Sammanfattning : The Hedgehog (HH) signaling pathway has critical roles in embryonic development and tumorigenesis. Aberrant activation of HH signaling has been known to be involved in several types of malignant tumors. GLI1 is a transcription factor that acts not only as the terminal effector but also represents a pathway target gene, amplifying the HH signal. LÄS MER
3. Mechanisms of hedgehog signaling activation in cancer development
Sammanfattning : Hedgehog (HH) signaling has an important role in many physiological processes, and deregulation of this pathway can result in a wide range of malignancies. The aim of this thesis is to identify and evaluate the role of various posttranscriptional mechanisms, including alternative splicing, RNA editing and antisense RNAs, associated with different key components of HH signaling. LÄS MER
4. Mechanisms acting on Hedgehog-GLI pathway and their therapeutic potential
Sammanfattning : Hedgehog signaling is crucial for diverse aspects of animal development, essential in regulating many cellular processes and is largely implicated in various forms of human cancer. However, many aspects of Hedgehog signaling are not completely understood. LÄS MER
5. Role of transcription factors in sensory neuron specification
Sammanfattning : The interface between our mind and the internal and external environments is the peripheral nervous system. A range of different sensory neuron subtypes detects cold, heat, pain, touch, and other stimuli. LÄS MER