Sökning: "Foxp3"

Visar resultat 11 - 15 av 96 avhandlingar innehållade ordet Foxp3.

  1. 11. The use of immunological biomarkers to improve individualization of postoperative radiotherapy in breast cancer

    Författare :Axel Stenmark Tullberg; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tumor-infiltrating lymphocytes; CD8; FOXP3; Radiotherapy; Breast cancer;

    Sammanfattning : Radiotherapy (RT) forms the cornerstone of most curative breast cancer treatment due to its well-established risk-reducing effect on local recurrences at the population level. However, there is heterogeneity regarding treatment benefits at the individual level, and research currently aims to better tailor treatment decisions based on tumor biology. LÄS MER

  3. 12. Immune maturation and lymphocyte characteristics in relation to early gut bacteria exposure

    Författare :Sophia Björkander; Eva Sverremark Ekström; Hanne Frøkiær; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Allergy; cell-free supernatant; chemokines; colonization; cytokines; FOXP3; immune-maturation; lactobacilli; lymphocytes; NK-cells; Staphylococcus aureus; unconventional T-cells; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : At birth, the immune system is immature and the gut microbiota influences immune maturation. Staphylococcus aureus (S. aureus) and lactobacilli are part of the neonatal gut microbiota and have seemingly opposite effects on the immune system. S. LÄS MER

  4. 13. FOXP3 and CTLA-4 : how isoforms regulate immunological tolerance

    Författare :Sang Liu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The maintenance of immunological tolerance is vital for preventing the immune system to damage normal tissues and physiological function of the body. CD4+FOXP3+ regulatory T (Treg) cells can suppress immune responses in a dominant manner and are essential for immunological tolerance. LÄS MER

  5. 14. Lineage stability and effector function of CD4+FOXP3+ regulatory T cells

    Författare :Christina Seitz; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : This work focuses on regulatory T (Treg) cell biology in the context of defining the role of forkhead box protein 3 (FOXP3) isoform expression and Treg mediated suppression via CTLA-4 (cytotoxic T-lymphocyte-associated protein 4). Treg cells are crucial in maintaining immunological tolerance and they in part act by suppressing dendritic cells (DCs). LÄS MER

  7. 15. Phenotype and function of CD25+ regulatory T cells in infants and adults

    Författare :Hanna Grindebacke; Göteborgs universitet; []
    Nyckelord :Immunology; CD4 CD25 FOXP3 regulatory T cells; human; allergy; IL-10; Systemic immunotherapy; migration; homing receptors; maturation;

    Sammanfattning : Active suppression by CD4+CD25+FOXP3+ regulatory T cells (Treg) is essential for the maintenance of peripheral tolerance to both self antigens and environmental antigens. Absence of these cells in human newborns leads to autoimmune and inflammatory disorders as well as allergic disease. LÄS MER