Sökning: "Foxa2"

Visar resultat 1 - 5 av 8 avhandlingar innehållade ordet Foxa2.

1. 1. Transcriptional regulation of thyroid development possible interplay of endoderm- and mesoderm-derived morphogenetic signals

   Författare :Jessica Westerlund; Göteborgs universitet; []
   Nyckelord :thyroid; congenital hypothyroidism; dysgenesis; Tbx1; Shh; Isl1; Foxa2; C-cells;

   Sammanfattning : Congenital hypothyroidism (CH) affects 1 in 3000 children and is the major cause of treatable mental retardation. Most cases are due to malformations of the gland, collectively named thyroid dysgenesis. The disease results from defective thyroid organogenesis during embryonic life. LÄS MER

3. 2. Origin and development of thyroid progenitor cells: experimental studies on endoderm, Foxa2 and EphA4

   Författare :Louise Andersson; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; sköldkörtel; embryogenes; organogenes; missbildningar;

   Sammanfattning : .... LÄS MER

4. 3. Embryonic Stem Cells: Differentiation into Insulin Producing Cells and Elimination of Damaged Proteins

   Författare :Gabriella Brolén; Stamcellscentrum (SCC); []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; oxidatively damaged proteins; diabetes; carbonyl; C-peptide; Medicine human and vertebrates ; insulin; human embryonic stem cell; 20S proteasome; AGE; Pdx1; proinsulin;

   Sammanfattning : This thesis includes two different parts: One focusing on how to induce human embryonic stem cells (hESCs) to differentiate into insulin producing cells by following the normal pancreatic development pathway. These cells have then the potential to be an unlimited source for diabetes regenerative medicine. LÄS MER

5. 4. Exploration of large molecular datasets using global gene networks : computational methods and tools

   Författare :Ashwini Priya Jeggari; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Defining gene expression profiles and mapping complex interactions between molecular regulators and proteins is a key for understanding biological processes and the functional properties of cells, which is therefore, the focus on numerous experimental studies. Small-scale biochemical analyses deliver high-quality data, but lack coverage, whereas high throughput sequencing reveals thousands of interactions which can be error-prone and require proper computational methods to discover true relations. LÄS MER

7. 5. Genome-Wide Studies of Transcriptional Regulation in Mammalian Cells

   Författare :Ola Wallerman; Claes Wadelius; Jussi Taipale; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ChIP; ChIP-chip; ChIP-seq; transcription factors; motif discovery; nucleosome positioning; HepG2; genome-wide; RNA-seq; Medical genetics; Medicinsk genetik; Medical Genetics; Medicinsk genetik;

   Sammanfattning : The key to the complexity of higher organisms lies not in the number of protein coding genes they carry, but rather in the intrinsic complexity of the gene regulatory networks. The major effectors of transcriptional regulation are proteins called transcription factors, and in this thesis four papers describing genome-wide studies of seven such factors are presented, together with studies on components of the chromatin and transcriptome. LÄS MER