Sökning: "Fluoxetine"

Visar resultat 1 - 5 av 33 avhandlingar innehållade ordet Fluoxetine.

  1. 1. The Effects of SSRI Treatment on Human Placenta and Embryo

    Författare :Helena Kaihola; Helena Åkerud; Inger Sundström-Poromaa; Jocelien Olivier; Olav Spigset; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; antenatal depression; embryo; embryo development; fluoxetine; gene expression; NGF; placenta; protein expression; Raf-1; ROCK; signaling pathways; SSRI; Medicinsk vetenskap; Medical Science; Obstetrik och gynekologi; Obstetrics and Gynaecology;

    Sammanfattning : During pregnancy, 4 - 7% of women suffer from major depressive disorder. When antidepressive treatment is needed, selective serotonin reuptake inhibitors (SSRIs) are the most commonly used. Although severe complications from SSRI treatment are rare, association with a number of adverse pregnancy and fetal outcomes has been found. LÄS MER

  2. 2. Psychotropic Pharmaceuticals in Aquatic Systems: An Ecological Perspective

    Författare :Melanie Hedgespeth; Enhet akvatisk ekologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; ecotoxicology; aquatic; trophic level; pharmaceutical; SSRI; beta-blocker; sertraline; fluoxetine; propranolol; fish; daphnia; snail; predator; prey; behavior; life history; multiple stressor;

    Sammanfattning : Psychotropic pharmaceuticals have been shown to exert a variety of sublethal effects on non-target organisms, even at low concentrations found in the environment (ng/L to µg/L); hence, the aim of my research has been to determine the individual-level effects of psychotropic pharmaceuticals (the selective serotonin reuptake inhibitors sertraline and fluoxetine, and the β-blocker propranolol) on behavioral and life history traits in freshwater organisms. Further, this research was directed towards assessing the potential large-scale impacts of these effects on population growth and predator-prey interactions (with community-level implications) via the application of traditional, ecological concepts and models. LÄS MER

  3. 3. Compulsive sexual behavior disorder: clinical characteristics and treatment with Naltrexone

    Författare :Josephine Savard; Jussi Jokinen; Katarina Görts Öberg; Cecilia Dhejne; Andreas Chatzittofis; Soili Lehto; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; compulsive sexual behavior disorder; Naltrexone; Fluoxetine; hypersexual disorder; sexual addiction; interpersonal violence; suicidal behavior; impulsivity; treatment; psykiatri; Psychiatry;

    Sammanfattning : Background: Compulsive Sexual Behavior Disorder (CSBD) is characterized by sexual preoccupation and loss of control of sexual behaviors causing distress, negative consequences, and impairment. Despite its high prevalence, the condition is understudied in terms of background factors and treatment. LÄS MER

  4. 4. Cytochrome P450 2C9, 2C19 and 2D6 genetic polymorphisms : Evaluation of genotyping as a tool for individualised treatment

    Författare :Maria Gabriella Scordo; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Drug metabolism; CYP2C9; CYP2C19; CYP2D6; genotyping; polymorphism; risperidone; warfarin; fluoxetine; phenytoin; extrapyramidal side-effects;

    Sammanfattning : Recent advances in the understanding of drug metabolism and the molecular biology of CYPs have generated great expectations regarding the use of pharmacogenetic testing as a tool to individualize drug treatment. The individual pharmacogenetic constitution might in principle predict the response to drugs, hormones and toxins. LÄS MER

  5. 5. Consequences of CYP2D6 polymorphism for the disposition and dynamics of tolterodine : a novel drug in the treatment of urinary bladder overactivity

    Författare :Niclas Brynne; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; active metabolite; CYP2D6; CYP3A4; disposition; drug interaction; fluoxetine; ketoconazole; metabolic ratio; pharmacokinetics; tolterodine;

    Sammanfattning : The pharmacokinetics and pharmacological effects of tolterodine were studied in man following administration of increasing oral and intravenous single-doses. The influence of metabolic phenotype in extensive and poor metabolizers of debrisoquine was determined. LÄS MER