Visar resultat 1 - 5 av 33 avhandlingar innehållade ordet Fluoxetine.
Sammanfattning : During pregnancy, 4 - 7% of women suffer from major depressive disorder. When antidepressive treatment is needed, selective serotonin reuptake inhibitors (SSRIs) are the most commonly used. Although severe complications from SSRI treatment are rare, association with a number of adverse pregnancy and fetal outcomes has been found. LÄS MER
Sammanfattning : Psychotropic pharmaceuticals have been shown to exert a variety of sublethal effects on non-target organisms, even at low concentrations found in the environment (ng/L to µg/L); hence, the aim of my research has been to determine the individual-level effects of psychotropic pharmaceuticals (the selective serotonin reuptake inhibitors sertraline and fluoxetine, and the β-blocker propranolol) on behavioral and life history traits in freshwater organisms. Further, this research was directed towards assessing the potential large-scale impacts of these effects on population growth and predator-prey interactions (with community-level implications) via the application of traditional, ecological concepts and models. LÄS MER
Sammanfattning : Background: Compulsive Sexual Behavior Disorder (CSBD) is characterized by sexual preoccupation and loss of control of sexual behaviors causing distress, negative consequences, and impairment. Despite its high prevalence, the condition is understudied in terms of background factors and treatment. LÄS MER
4. Cytochrome P450 2C9, 2C19 and 2D6 genetic polymorphisms : Evaluation of genotyping as a tool for individualised treatment
Sammanfattning : Recent advances in the understanding of drug metabolism and the molecular biology of CYPs have generated great expectations regarding the use of pharmacogenetic testing as a tool to individualize drug treatment. The individual pharmacogenetic constitution might in principle predict the response to drugs, hormones and toxins. LÄS MER
5. Consequences of CYP2D6 polymorphism for the disposition and dynamics of tolterodine : a novel drug in the treatment of urinary bladder overactivity
Sammanfattning : The pharmacokinetics and pharmacological effects of tolterodine were studied in man following administration of increasing oral and intravenous single-doses. The influence of metabolic phenotype in extensive and poor metabolizers of debrisoquine was determined. LÄS MER