Sökning: "Florin Sirzén"

Hittade 1 avhandling innehållade orden Florin Sirzén.

1. 1. Molecular aspects of cellular radiosensitivity in small cell lung carcinoma

   Författare :Florin Sirzén; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :lung carcinoma; radiosensitivity; DNA double-strand breaks; DNA-dependent protein kinase; cell cycle checkpoints; apoptosis;

   Sammanfattning : To clarify some important molecular aspects of radiosensitivity (RS) in small cell (SCLC) compared with non small cell (NSCLC) lung carcinoma, five studies focusing on DNA damage repair, cell cycle checkpoints and apoptosis were performed. As repair of DNA double-strand breaks (DNA dsb), a critical DNA lesion, may be an important determinant of cellular RS, induction and rejoining of DNA dsb were studied using pulsed field gel electrophoresis in a radiosensitive SCLC line, U-1285 and a radioresistant NSCLC line, U-1810 (paper I). LÄS MER