Sökning: "Fiber Toxicity"

Visar resultat 1 - 5 av 12 avhandlingar innehållade orden Fiber Toxicity.

  1. 1. GaP and GaInP nanowires as model particles for in vivo fiber toxicity studies

    Författare :Karl Adolfsson; Fasta tillståndets fysik; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Fluorescent Nanowires; Fiber Toxicity; Drosophila melanogaster; Daphnia magna; Fysicumarkivet A:2017:Adolfsson;

    Sammanfattning : .... LÄS MER

  3. 2. Integrated Cellulosic Wood Aerogel Structures

    Författare :Jonas Garemark; Yuanyuan Li; Lars Berglund; Gustav Nyström; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Aerogel; cellulose; energy harvesting; ionic liquids; nanotechnology; wood; thermal insulation; Fiber- och polymervetenskap; Fibre and Polymer Science;

    Sammanfattning : Highly porous aerogels based on renewable materials that possess structural functionality are appealing for sustainable energy regulation and harvesting. Achieving structural anisotropy provides advantageous directional diffusion and mechanical strength, however, introduces great engineering challenges, such as complex, costly, and time-consuming processing. LÄS MER

  4. 3. Methods for Preclinical Evaluation of Cytotoxic Drugs : With Special Reference to the Cyanoguanidine CHS 828 and Hollow Fiber Method

    Författare :Saadia Bashir Hassan; Elin Lindhagen; Rolf Larsson; Mats O Karlsson; Mustapha Hassan; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; CHS 828; in vitro; in vivo; hollow fiber; models; NF-kB; Farmakologi; Pharmacological research; Farmakologisk forskning;

    Sammanfattning : The novel cyanoguanidine CHS 828 has shown promising antitumor activity in many in vitro and in vivo studies. The long-term 14 days in vitro hollow fiber cultures, where tumor cells from different tumor cell lines were cultured inside semipermeable fibers, were more resistant to CHS 828 and other cytotoxic drugs than the shorter-term 3 days cultures. LÄS MER

  5. 4. Application of new methodology for preclinical development of anticancer drugs : With special focus on camptothecin derivatives and the cyanoguanidine CHS 828

    Författare :Elin Jonsson; Uppsala universitet; []
    Nyckelord :Medical sciences; drug development; hollow-fiber model; FMCA; human tumour cell; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; klinisk farmakologi; Clinical Pharmacology;

    Sammanfattning : This work describes the development and evaluation of new methods for preclinical anticancer drug development. The methods were specifically applied to study camptothecin analogues and the new compound CHS 828 (N-(4-chlorophenoxyhexyl)-N'-cyano-N"-4-pyridylguanidine) currently in early clinical trials. LÄS MER

  7. 5. Analyses of Dose-Response and Mechanistic Action of Different Anti-Cancer Drugs for Neuroendocrine Tumor Cell Lines

    Författare :Dhana E Larsson; Dan Granberg; Sadia Hassan; Kjell Öberg; Jens F Rehfeld; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer drugs; Screening; Hollow Fiber model; Apoptosis; Oncology; Onkologi;

    Sammanfattning : Cancer is a disease with poor response rates on available treatments. Problems with resistance and intolerance against cancer drugs are major reasons for failure of the drugs. The need to discover new cancer drugs is important. In this thesis screening of new cancer drugs and evaluation of their mechanism of action are discussed. LÄS MER