Sökning: "Fel d 1"

Visar resultat 1 - 5 av 36 avhandlingar innehållade orden Fel d 1.

  1. 1. SOD1 misfolding and aggregation in ALS : in the light of conformation-specific antibodies

    Författare :Manuela Lehmann; Jonathan D. Gilthorpe; Stefan L. Marklund; Thomas Brännström; Ulrika Nordström; Elizabeth Fisher; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; ALS; antibodies; SOD1; disordered SOD1; patient-derived models; low oxygen tension; Immunotherapy;

    Sammanfattning : Mutations in the superoxide dismutase 1 (SOD1) gene are linked to the progressive neurodegenerative disease amyotrophic lateral sclerosis (ALS). ALS-associated mutations affect the stability of the SOD1 protein and promote its unfolding. As a consequence, disordered SOD1 species can misfold and accumulate into insoluble aggregates. LÄS MER

  2. 2. Molecular characterisation of major allergens from mite (Lep d 2) and cat (Fel d 1)

    Författare :Liselotte Kaiser; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Allergens allergy; cat; mite; immunotherapy; recombinant allergens.;

    Sammanfattning : The prevalence of allergic disease has increased significantly during the last decades and today more than 30% of the Swedish population is affected. By using recombinant allergens, diagnostics and treatment can be improved and the mechanisms of allergic reactions may be further explored. LÄS MER

  3. 3. The Use of Landweber Algorithm in Image Reconstruction

    Författare :Touraj Nikazad; Tommy Elfving; George Baravdish; Linköpings universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; convex feasibility; projection methods; simultaneous algorithms; iterative methods; stopping rules; semi-convergence; Numerical analysis; Numerisk analys;

    Sammanfattning : Ill-posed sets of linear equations typically arise when discretizing certain types of integral transforms. A well known example is image reconstruction, which can be modelled using the Radon transform. After expanding the solution into a finite series of basis functions a large, sparse and ill-conditioned linear system arises. LÄS MER

  4. 4. Activation of lung epithelial cells by group 2 mite allergens

    Författare :Camilla Österlund; Anders Bucht; Thomas Sandström; Jan Wahlström; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; group 2 mite allergens; Der p 2; Der f 2; Eur m 2; Lep d 2; airway epithelium; lungmedicin; Lung Medicine;

    Sammanfattning : Throughout many parts of the world house dust mites (HDM) are considered as a major source of indoor aeroallergens and they are powerful inducers of allergic diseases. Proteolytic HDM allergens are recognised as being able to directly activate respiratory epithelial cells and thereby actively participate in innate immune responses. LÄS MER

  5. 5. Development of a Sel-tag for multimodality imaging and studies of mammalian thioredoxin reductase 1

    Författare :Qing Cheng; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Selenocysteine (Sec; U in one-letter code), the 21st amino acid existing in all selenoproteins, has unique biochemical properties due to its selenium atom, including a low pKa and a high reactivity with many electrophilic agents. When a selenoprotein is translated, the insertion of Sec occurs at a UGA codon, normally yielding translational termination. LÄS MER