Sökning: "Fel d 1"
Visar resultat 1 - 5 av 36 avhandlingar innehållade orden Fel d 1.
Sammanfattning : Mutations in the superoxide dismutase 1 (SOD1) gene are linked to the progressive neurodegenerative disease amyotrophic lateral sclerosis (ALS). ALS-associated mutations affect the stability of the SOD1 protein and promote its unfolding. As a consequence, disordered SOD1 species can misfold and accumulate into insoluble aggregates. LÄS MER
Sammanfattning : The prevalence of allergic disease has increased significantly during the last decades and today more than 30% of the Swedish population is affected. By using recombinant allergens, diagnostics and treatment can be improved and the mechanisms of allergic reactions may be further explored. LÄS MER
Sammanfattning : Ill-posed sets of linear equations typically arise when discretizing certain types of integral transforms. A well known example is image reconstruction, which can be modelled using the Radon transform. After expanding the solution into a finite series of basis functions a large, sparse and ill-conditioned linear system arises. LÄS MER
Sammanfattning : Throughout many parts of the world house dust mites (HDM) are considered as a major source of indoor aeroallergens and they are powerful inducers of allergic diseases. Proteolytic HDM allergens are recognised as being able to directly activate respiratory epithelial cells and thereby actively participate in innate immune responses. LÄS MER
5. Development of a Sel-tag for multimodality imaging and studies of mammalian thioredoxin reductase 1
Sammanfattning : Selenocysteine (Sec; U in one-letter code), the 21st amino acid existing in all selenoproteins, has unique biochemical properties due to its selenium atom, including a low pKa and a high reactivity with many electrophilic agents. When a selenoprotein is translated, the insertion of Sec occurs at a UGA codon, normally yielding translational termination. LÄS MER