Sökning: "Fc receptors"

Visar resultat 16 - 20 av 53 avhandlingar innehållade orden Fc receptors.

  1. 16. Structure and Interactions of Human IgG-Fc

    Författare :Daniel Kanmert; Karin Enander; Thomas Skogh; Jonas Wetterö; Sara Snogerup; Linköpings universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP;

    Sammanfattning : This thesis involves structure and interaction studies of the Fc fragment of human IgG. For this purpose, hIgG-Fc of different subclasses were cloned and expressed in the eukaryotic host Pichia pastoris, where relevant protein modification at the post-translational level can be obtained. LÄS MER

  3. 17. Mast cells: bad enemies or good friends? : A study of the effects of IgG immune complexes on mast cell biology

    Författare :Lisa M Larsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mast cell; Fc receptor; Apoptosis; Immune complex; Adjuvant; CTA1-DD.;

    Sammanfattning : Mast cells are classically defined as bad enemies to human health due to their critical involvement in IgE-dependent allergy by virtue of the expression of the high affinity IgE receptor, FcgammaRI, on these cells. However, mouse mast cells also express FcgammaRIIB and FcgammaRIIIA, two receptors that bind IgG especially in the form of IgG immune complexes. LÄS MER

  4. 18. Human adipose tissue. Genes predominantly expressed in the visceral depot and in hypertrophic adipocytes

    Författare :Jenny Palming; Göteborgs universitet; []
    Nyckelord :obesity; type 2 diabetes; adipose tissue depots; complement system; plasma cell; Fc receptor; serum amyloid A; NAD P H:quinone oxidoreductase 1; DNA microarray;

    Sammanfattning : The obesity prevalence is increasing worldwide and obesity is closely linked to type 2 diabetes and cardiovascular disease. Both visceral fat accumulation and enlarged adipocyte size are risk factors for obesity related metabolic disorders. LÄS MER

  5. 19. Function and Regulation of B-cell Subsets in Experimental Autoimmune Arthritis

    Författare :Anna-Karin E. Palm; Sandra Kleinau; Susanna Cardell; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; B cells; marginal zone; autoimmune arthritis; spleen; lymph node; antigen presentation; Fc gamma receptor IIb; complement receptors 1 and 2; mast cells; Biologi med inriktning mot molekylär immunologi; Biology with specialization in Molecular Immunology;

    Sammanfattning : B lymphocytes play a significant role in autoimmune arthritis, with their function stretching beyond autoantibody production to cytokine secretion and presentation of autoantigen. However, the involvement and activation of different B-cell subset in the autoimmune response is not fully clear. LÄS MER

  7. 20. Immunoglobulin-Fc receptor interactions in cytotoxicity and phagocytosis mediated by lymphocytes and monocytes

    Författare :Christer Öhlander; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Antibody dependent cellular cytotoxicity (ADCC) and phagocytosis mediated by lymphocytes and monocytes depend on IgG-binding Fc receptors on the effector cells. Properties of the immunoglobulin-Fc receptor interactions of human lymphocytes and monocytes were investigated using 51Cr release assays for detection of cytolysis or phagocytosis of target erythrocytes. LÄS MER