Sökning: "Fatty acid transport protein"

Visar resultat 21 - 25 av 25 avhandlingar innehållade orden Fatty acid transport protein.

  1. 21. The role of GH in the regulation of energy homeostasis, lipid metabolism and cardiovascular function in transgenic mice

    Författare :Bob Olsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; growth hormone; cardiovascular disease; energy homeostasis; lipid metabolism; transgenic mice;

    Sammanfattning : The aim of this thesis was, using two transgenic models, to investigate some metabolic diseases associated with acromegaly e.g. hypertension and alterations in lipid and lipoprotein metabolism. LÄS MER

  3. 22. Nutrient-regulated skeletal muscle metabolism and circadian clock

    Författare :Laura Sardon Puig; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The prevalence of obesity has tripled in the last four decades, becoming a major risk for the development of cardiometabolic diseases such as type 2 diabetes. Obesity is associated with pathological storage of lipids in skeletal muscle, causing a major disturbance in metabolism. LÄS MER

  4. 23. Genetic and functional studies of MTTP and PLIN2 in relation to metabolic and cardiac dysfunction

    Författare :Anna Aminoff; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Lipids including triglycerides, cholesterol, cholesterol esters and fatty acids are important sources for energy production, act as building blocks for intracellular compartments, are involved in numerous biological pathways and may act as signal molecules. Lipids are transported in blood as lipoproteins between organs, where they are immediately used in cellular processes or stored as cytosolic lipid droplets. LÄS MER

  5. 24. Transcriptional regulation of healthy and diabetic pancreatic beta-cell gene expression

    Författare :Hamedeh Ghanaat-pour; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Hyperglycemia, deficient insulin secretion, and insulin resistance are the characteristic pathogenetic features of type 2 diabetes (T2D), hallmarked by functional and survival defects of the insulin-producing islet beta-cell. The primary pathogenesis of T2D probably involves both genetic and environmental forces, and hyperglycemia and very commonly hyperlipidemia might further aggravate beta-cell dysfunction. LÄS MER

  7. 25. Fighting cardiometabolic disease : validation of new experimental models and therapeutic targets

    Författare :Mirko Enea Minniti; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The prevalence of cardiometabolic diseases (CMD) such as atherosclerotic cardiovascular diseases, type 2 diabetes mellitus and nonalcoholic fatty liver disease (NAFLD), has grown dramatically during the last decades. Hence, massive research efforts are allocated to identify the pathophysiological mechanisms and new therapeutic targets for these morbidities. LÄS MER