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Visar resultat 1 - 5 av 25 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Intestinal Gene Expression Profiling and Fatty Acid Responses to a High-fat Diet

   Författare :Jonathan Cedernaes; Helgi B Schiöth; Robert Fredriksson; Anders Jacobsson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Adhesion GPCR; delta-5 desaturase; delta-6 desaturase; desaturase index; Diet-induced obesity; estimated desaturase activity; fatty acid composition; gas chromatography; gastrointestinal tract; G-protein coupled receptor; high-fat diet; intestine; linoleic acid; liver; mRNA expression; palmitoleic acid; plasma; phospholipids; proximodistal; RT-qPCR; solute carrier; SCD-1; SCD-16; SCD-18; stearoyl-CoA desaturase; subcutaneous adipose tissue; subsection; triacylglycerols.; Medical Genetics; Medicinsk genetik; Nutrition; Nutrition; Näringslära; Nutrition;

   Sammanfattning : The gastrointestinal tract (GIT) regulates nutrient uptake, secretes hormones and has a crucial gut flora and enteric nervous system. Of relevance for these functions are the G protein-coupled receptors (GPCRs) and the solute carriers (SLCs). LÄS MER

3. 2. Multidimensional engineering for the production of fatty acid derivatives in Saccharomyces cerevisiae

   Författare :Yating Hu; Chalmers tekniska högskola; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; protein engineering; Saccharomyces cerevisiae; fatty acid derivatives; metabolic engineering; tolerance; transporter;

   Sammanfattning : Saccharomyces cerevisiae , also known as budding yeast, has been important for human society since ancient time due to its use during bread making and beer brewing, but it has also made important contribution to scientific studies as model eukaryote. The ease of genetic modification and the robustness and tolerance towards harsh conditions have established yeast as one of the most popular chassis in industrial-scale production of various compounds. LÄS MER

4. 3. Structural Studies of Echinococcus granulosus Fatty-acid-binding Protein 1 and Human Semicarbazide-sensitive Amine Oxidase

   Författare :Emma Jakobsson; Gerard Kleywegt; Andrea Mattevi; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; semicarbazide-sensitive amine oxidase; vascular adhesion protein-1; copper-containing amine oxidase; fatty-acid-binding protein; Echinococcus granulosus; crystal structure; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi;

   Sammanfattning : The parasite Echinococcus granulosus causes hydatid disease, a major zoonosis. A fatty-acid-binding protein, EgFABP1, is important for the parasite, as it must acquire almost all its lipids from its environment or the host. The structure of EgFABP1 has been solved and refined to 1.6 Å resolution. LÄS MER

5. 4. Fatty acid transport proteins : candidate genes for the insulin resistance syndrome

   Författare :Karl Gertow; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Fatty acid transport protein; fatty acid; triglyceride; lipoprotein; obesity; insulin resistance; adipose tissue; polymorphism; association study; gene expression;

   Sammanfattning : The insulin resistance syndrome is characterised by insulin resistance, obesity, hypertension, and a typical dyslipidaemia, predisposing to diabetes and cardiovascular disease. Metabolic disturbances of the insulin resistance syndrome include dysregulation of fatty acid (FA) homeostasis, for which adipose tissue serves a critical function. LÄS MER

7. 5. Influence of strain, feed profile and cultivation technique on the lipid structure and membrane function in Escherichia coli

   Författare :Atefeh Shokri; KTH; []
   Nyckelord :Escherichia coli; phospholipid and fatty acid regulation. fed-batch; continuous cultivation; leakage; protein transport;

   Sammanfattning : The phospholipid and fatty acids content of the Escherichiacoli membrane were investigated during changes of feed rate,cultivation technique and host strains.During continuous cultivation it was shown that the leakageof periplasmic protein to the medium had an optimum at 0.3 h-1,resulting in transport of 20% of the total recombinant product. LÄS MER