Sökning: "Farmaceutisk vetenskap"
Visar resultat 21 - 25 av 87 avhandlingar innehållade orden Farmaceutisk vetenskap.
21. Stress, Drugs and Neuroscience : Neurobiological Effects of Social Stressors and Drug Exposure in Young and Adolescent Rats
Sammanfattning : Experiences early in life or during adolescence modulate neuronal networks in the immature brain and consequently lay the foundation for future susceptibility or resilience towards psychiatric disorders. The objective in this thesis is to understand, in part, how the surrounding environment shapes the brain of a young individual. LÄS MER
22. Mechanism-based modeling of biological processes involved in oral absorption
Sammanfattning : For orally administered drugs, the rate and extent of absorption are governed by the physiology of the gastrointestinal tract, the characteristics of the dosage form and the physico-chemical properties of the drug. This thesis primarily aimed to improve the mechanistic understanding and the predictability of processes involved in the absorption of orally administered drugs using a population modeling approach. LÄS MER
23. Translational Aspects of Blood-Brain Barrier Transport and Brain Distribution of Drugs in Health and Disease
Sammanfattning : A high unmet medical need in the area of CNS diseases coincides with high failure rates in CNS drug development. Efficient treatment of CNS disease is constrained by limited entrance of drugs into the brain owing to the blood-brain barrier (BBB), which separates brain from blood. LÄS MER
24. Deep learning approaches for image cytometry: assessing cellular morphological responses to drug perturbations
Sammanfattning : Image cytometry is the analysis of cell properties from microscopy image data and is used ubiquitously in basic cell biology, medical diagnosis and drug development. In recent years deep learning has shown impressive results for many image cytometry tasks, including image processing, segmentation, classification and detection. LÄS MER
25. Drug Delivery to the Brain by Liposomes : Understanding Factors Governing Delivery Outcomes In Vivo
Sammanfattning : The blood-brain barrier (BBB) is the primary obstacle for efficient drug delivery to the central nervous system (CNS). One promising strategy to enhance brain delivery is to utilize nanocarriers (NC), e.g., liposomes, encapsulating CNS drugs. LÄS MER