Sökning: "Farmaceutisk farmakologi"
Visar resultat 16 - 20 av 59 avhandlingar innehållade orden Farmaceutisk farmakologi.
16. Catalytic Properties and Tissue Distribution of Cytochrome P450 4F8 and 4F12 : Expression of CYP4F8 in Eye Tissues and Psoriatic Lesions
Sammanfattning : The human cytochrome P450 (CYP) family of monooxygenases is important for metabolism of drugs and endogenous compounds, e.g., vitamin A and D, cholesterol, steroids, fatty acids, and eicosanoids. This thesis describes the tissue distribution, catalytic properties, and possible function of CYP4F8 and CYP4F12. LÄS MER
17. The Role of Cyclooxygenase-2 in Models of Epilepsy and Traumatic Brain Injury : Effects of Selective Cyclooxygenase-2 Inhibitors
Sammanfattning : Cyclooxygenase-2 (COX-2) catalyses prostaglandin synthesis from arachidonic acid during inflammation. COX-2 is expressed in the normal brain and is induced in neurological disorders. There is evidence that COX-2 is involved in secondary events leading to cell death in the brain. LÄS MER
18. Arachidonic acid metabolism in corneal epithelial cells : Identification of lipoxygenase isoforms
Sammanfattning : The metabolism of arachidonic acid in the human cornea was investigated and compared with the metabolism in cattle and primates. All three species showed significant arachidonic acid metabolism inthe epithelium, whereas the activity in the stroma and the endothelium was low or undetectable. LÄS MER
19. The Role of the Melanocortin System in Linking Energy Homeostasis with Reward Mechanisms
Sammanfattning : There is evidence of a link between peripheral signals of energy homeostasis and reward mechanisms. A hypothesis was formulated that the melanocortin (MC) system is part of this link. The hypothesis was tested by a series of receptor expression and neurochemical studies in rats. LÄS MER
20. Involvement of the Opioid System in High Alcohol Consumption : Environmental and Genetic Influences
Sammanfattning : It is well accepted that both inherent and environmental factors influence the pathogenesis of alcohol dependence. This thesis investigates the role of the opioid system in the initiation and maintenance of high ethanol intake. LÄS MER