Sökning: "False positive signals"

Visar resultat 6 - 9 av 9 avhandlingar innehållade orden False positive signals.

  1. 6. Analysis of signaling pathway activity in single cells using the in situ Proximity Ligation Assay

    Författare :Linda Arngården; Ola Söderberg; Niclas Karlsson; Uppsala universitet; []
    Nyckelord :cell signaling; Wnt; Hippo; TGFB; Molekylär medicin; Molecular Medicine;

    Sammanfattning : A cell that senses signals from its environment uses proteins for signal transduction via post translational modifications (PTMs) and protein- protein interactions (PPIs) from cell membrane into the nucleus where genes controlling cell proliferation, differentiation and apoptosis can be turned on or off, i.e. LÄS MER

  3. 7. Making Visible the Proximity Between Proteins

    Författare :Carl-Magnus Clausson; Ola Söderberg; Jens Coorssen; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Proximity ligation assay; In situ PLA; rolling circle amplification; protein interaction; protein-protein interaction; in situ; single cell; single molecule; protein complex; antibody; cancer; tissue section; microscopy; image analysis; system biology; multiplex; dynamic range; methods development; systems biology; Molekylär medicin; Molecular Medicine;

    Sammanfattning : Genomic DNA is the template of life - the entity which is characterized by a self-sustaining anatomical development, regulated signaling processes, the ability to reproduce and to respond to stimuli. Through what is classically known as the central dogma, the genome is transcribed into mRNA, which in turn is translated into proteins. LÄS MER

  4. 8. Amyloid-β Protofibrils in Alzheimer´s Disease : Focus on Antibodies, Inflammation and Astrocytes

    Författare :Sofia Söllvander; Lars Lannfelt; Anna Erlandsson; Frida Ekholm-Pettersson; Linda Söderberg; Pär Gellerfors; Martin Hallbeck; Uppsala universitet; []
    Nyckelord :Alzheimer s Disease; Amyloid-beta; Protofibrils; ELISA; ELISpot; Astrocyte; Monoclonal Antibody; Immunofluorescence; Medicinsk vetenskap; Medical Science;

    Sammanfattning : Soluble amyloid-beta (Aβ) aggregates, including Aβ protofibrils, play a central role in Alzheimer’s disease (AD) and constitute a potential diagnostic biomarker and a therapeutic target. Aβ protofibrils promote synapse dysfunction and neurodegeneration, but the mechanisms behind these effects remain unclear. LÄS MER

  5. 9. Expression and interaction studies of recombinant human monoclonal antibodies

    Författare :Daniel X Johansson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The highly specific binding characteristics of monoclonal antibodies (mAbs) have made them one of the most useful tools in the fields of research and biotechnology where they provide the basis for a large number of diagnostic and technical assays. In recent years, with the advent of techniques to generate fully human antibodies, mAbs have also emerged as a new important class of therapeutics. LÄS MER