Sökning: "Factor substitution"

Visar resultat 6 - 10 av 95 avhandlingar innehållade orden Factor substitution.

  1. 6. Computer-Assisted Organic Synthesis. Addition to Carbonyl Carbons and Aromatic Substitution

    Författare :Ingvar Lagerstedt; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; CAOS; torsional strain; selectivity; aromatic substitution reaction;

    Sammanfattning : This thesis concerns the computer-assisted modelling of additions to ketones and aromatic substitution, and how this modelling can be used within an existing program for synthesis planning. I include a review of existing computer-assisted organic synthesis (CAOS) programs, and discuss how some of these programs deal with knowledge representation. LÄS MER

  3. 7. Examining the competition for forest resources in Sweden using factor substitution analysis and partial equilibrium modelling

    Författare :Anna Olsson; Tommy Lundgren; Luleå tekniska universitet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Economics; Nationalekonomi;

    Sammanfattning : The overall objective of the thesis is to analyse the procurement competition for forestresources in Sweden. The thesis consists of an introductory part and two self-containedpapers. LÄS MER

  4. 8. Quantum Chemical Studies of Chemotherapeutic Drug Cisplatin : Activation and Binding to DNA

    Författare :Johan Raber; David van der Spoel; Paolo Carloni; Uppsala universitet; []
    Nyckelord :Quantum chemistry; cisplatin; quantum chemistry; DNA; density functional theory; activation; JM118; substitution reaction; Platinum; guanine; adenine; cytostatic drug; aquation; anation; activation; Kvantkemi;

    Sammanfattning : The serendipitous discovery of the potent cytotoxic properties of cisplatin brought about a revolution in the treatment of certain types of cancer, but almost fifty years later, there still remain unknown areas in the chemistry of cisplatin. There are questions regarding which form of the drug reaches its DNA target, or why certain DNA sequences are more preferred than others for reaction with cisplatin. LÄS MER

  5. 9. Mutation Analysis and Hypercholesterolemia: Studies in FH patients and in healthy middle-aged men with high, low, or increasing cholesterol levels during a six-year follow-up (the CRISS study)

    Författare :Ulf Ekström; Avdelningen för klinisk kemi och farmakologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Klinisk kemi; Clinical chemistry; LDL receptor; Mutation; risk factor; FH; familial hypercholesterolemia;

    Sammanfattning : Our aims were to characterize familial hypercholesterolemia (FH) in a Swedish FH population and to further elucidate the clinical expression and treatment response in relation to genotype. Secondly, we wanted to identify gene variants, which may have impact on cholesterol levels in apparently healthy subjects. LÄS MER

  7. 10. Insulin-like growth factor binding protein-3 : structure and function

    Författare :Maria Ahlsén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Insulin-like growth factor (IGF) -I and -II share structural homology with insulin. Their receptors and intracellular signaling are similar. Consequently, the biological actions of IGFs and insulin are overlapping. Insulin is secreted on demand depending on e. LÄS MER