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Hittade 2 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Development of Novel Macrocyclic Inhibitors of Protein-Protein Interactions : Applied to the Keap1-Nrf2 Complex

   Författare :Fabio Begnini; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chemistry with specialization in Organic Chemistry; Kemi med inriktning mot organisk kemi;

   Sammanfattning : .... LÄS MER

3. 2. Discovery of Novel Macrocyclic Ligands for Difficult Targets : Applications to Natural Product Derived Keap1 Inhibitors

   Författare :Fabio Begnini; Jan Kihlberg; Anders Bach; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Macrocycles; Keap1-Nrf2; Protein-protein interactions; Natural products;

   Sammanfattning : The development of small-molecule ligands for biological targets that possess large, featureless or highly polar binding sites is a challenging task. This thesis is focused on a novel lead generation strategy to identify macrocyclic ligands for difficult-to-drug targets, as well as on the relationship between cell permeability and the conformations of macrocycles. LÄS MER