Sökning: "Fabio Begnini"
Hittade 2 avhandlingar innehållade orden Fabio Begnini.
1. Development of Novel Macrocyclic Inhibitors of Protein-Protein Interactions : Applied to the Keap1-Nrf2 Complex
Sammanfattning : .... LÄS MER
2. Discovery of Novel Macrocyclic Ligands for Difficult Targets : Applications to Natural Product Derived Keap1 Inhibitors
Sammanfattning : The development of small-molecule ligands for biological targets that possess large, featureless or highly polar binding sites is a challenging task. This thesis is focused on a novel lead generation strategy to identify macrocyclic ligands for difficult-to-drug targets, as well as on the relationship between cell permeability and the conformations of macrocycles. LÄS MER
Resultatsidor:
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