Sökning: "FZD6"
Hittade 4 avhandlingar innehållade ordet FZD6.
1. Molecular Studies of Diamond-Blackfan Anemia and Congenital Nail Dysplasia
Sammanfattning : The aim of this thesis is to investigate the effect of genetic mutations on the pathophysiology of two human disorders: Diamond-Blackfan Anemia (DBA) and isolated congenital nail dysplasia. The first part of this thesis (Paper I-III) investigates the mechanism associated with DBA. LÄS MER
2. Structural and functional analysis of WNT receptors : with emphasis on FZD6
Sammanfattning : Many cellular processes are dependent on the activation of G protein-coupled receptors (GPCRs). The development of drugs that can specifically target GPCRs and their corresponding signalling cascades is of high interest. LÄS MER
3. Frizzled as a G protein-coupled receptor : the role of disheveled and G proteins for signal specification
Sammanfattning : Cell communication governed and coordinated by the WNT family of lipoglycoproteins comprises essential physiological processes active throughout the life-span of metazoan organisms. In humans, severe diseases and congenital birth defects have been directly linked to disturbances in WNT signaling. LÄS MER
4. Novel insights into dishevelled and frizzled function
Sammanfattning : The formation of a multicellular body during embryonic development is one of the most fascinating processes in biology. The cells are in constant communication and must be precisely coordinated. Several essential signalling pathways have been identified in cell-to-cell signal transmission. LÄS MER