Sökning: "FVIIa"

Visar resultat 1 - 5 av 17 avhandlingar innehållade ordet FVIIa.

  1. 1. Coagulation in children with liver disease

    Författare :Maria Magnusson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :FVIIa;

    Sammanfattning : About 100 new children in Sweden require care at a tertiary pediatric ward each year for severe liver disease. These children are at risk for both severe gastrointestinal bleeding, which may be life threatening, and intra- or extrahepatic thrombosis. LÄS MER

  3. 2. The Role of Innate Immunity in Islet Transplantation : Clinical and Experimental Studies

    Författare :Lisa Moberg; Bo Nilsson; Olle Korsgren; Kristina Nilsson Ekdahl; Rolf Larsson; David Harlan; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; diabetes; islet transplantation; islet of Langerhans; coagulation activation; IBMIR; tissue factor; thrombin; inactivated FVIIa; melagatran; neutrophilic granulocyte; Immunologi; Immunology; Immunologi;

    Sammanfattning : Clinical islet transplantation is an emerging procedure to cure type 1 diabetes. The graft is implanted by infusion into the liver through the portal vein. A major obstacle that still needs to be overcome is the requirement for islets from multiple donors to achieve insulin independence. LÄS MER

  4. 3. Tissue Factor in Complex : Studies of interactions between blood coagulation proteins

    Författare :Karin Carlsson; Magdalena Svensson; Susanne Wisén; Linköpings universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP;

    Sammanfattning : Many biological processes rely on specific protein-protein interactions, for example immune responses, cell signaling, transcription, and blood coagulation. Blood coagulation is initiated when a vessel wall is damaged, exposing tissue factor (TF) to the circulating factor VII/factor VIIa (FVII/FVIIa) which results in the formation of the TF:FVIIa complex and thereby the initiation of blood coagulation. LÄS MER

  5. 4. Tissue Factor regulation, signaling and functions beyond coagulation with a focus on diabetes

    Författare :Desireé Edén; Agneta Siegbahn; Sofia Ramström; Uppsala universitet; []
    Nyckelord :Tissue factor; diabetes; cell signaling; coagulation; beta cells; adipocytes; apoptosis; lipolysis; micro RNA; Medicinsk vetenskap; Medical Science;

    Sammanfattning : Background: Tissue factor (TF) is a 47 kDa transmembrane glycoprotein best known for initiating the coagulation cascade upon binding of its ligand FVIIa. Apart from its physiological role in coagulation, TF and TF/FVIIa signaling has proved to be involved in diseases such as diabetes, cancer and cardiovascular diseases. LÄS MER

  7. 5. Molecular Probing of Local Protein-Protein Interactions : Studies of the tissue factor, factor VIIa complex formation

    Författare :Maria Österlund; Mikael Oliveberg; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Protein-protein interactions are intrinsic to virtually all cellular processes. However, very little is known about the dynamics of the formation of protein complexes or the order of events that direct the association between two protein molecules (the association pathway), especially when different interacting surfaces are involved. LÄS MER