Sökning: "FUS-DDIT3"

Visar resultat 6 - 8 av 8 avhandlingar innehållade ordet FUS-DDIT3.

  1. 6. Clinical and molecular studies of liposarcoma

    Författare :Katarina Engström; Göteborgs universitet; []
    Nyckelord :Liposarcoma; radiotherapy; prognostic factors; transfection; FUD-DDIT3; adipogenesis; microarray expression analysis; cell cycle; immunohistochemistry;

    Sammanfattning : Aims: (1) To analyse clinicopathological characteristics, treatment and outcome of liposarcoma, and to determine whether, and how, the Scandinavian Sarcoma Group (SSG) treatment guidelines were followed; (2) to analyse tumour volume and morphology response after radiotherapy in myxoid/round cell liposarcoma (MLS/RCLS); (3) to examine the role of the MLS-specific fusion gene FUS-DDIT3 in development of liposarcomas; and (4) to analyse expression patterns of cell cycle regulating proteins in MLS. Methods: (1) A total of 319 liposarcomas reported between 1986?1998 to the SSG Register were reviewed. LÄS MER

  3. 7. FET fusion oncoproteins in sarcoma tumorigenesis - lnteractions with the SWI/SNF chromatin remodeling complex and epigenetic effects

    Författare :Malin Lindén; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ewing sarcoma; Epigenetics; FET fusion oncoproteins; Myxoid liposarcoma; Proteomics; SWI SNF BAF chromatin remodeling complex;

    Sammanfattning : The FET family of fusion oncoproteins containing the N-terminal of either FUS, EWSR1 or TAF15 together with a transcription factor partner is the characteristic oncogenic driver of more than 20 types of sarcoma and leukemia, including myxoid liposarcoma and Ewing sarcoma. The FET oncoproteins are thought to function as aberrant transcription factors, however, the exact oncogenic mechanism remains to be elucidated. LÄS MER

  4. 8. Gene expression profiling with real-time PCR

    Författare :Anders Ståhlberg; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; single cell biology; reverse transcription; LightUp probe; cancer diagnostics; real-time PCR; gene expression profiling; tumor biology;

    Sammanfattning : The sequence of the entire human genome is available today, and this information can be used to understand, characterize, and treat complex diseases such as cancer. Many cellular functions related to survival, growth and differentiation are reflected in the gene expression pattern, and the ability to quantify transcription levels of specific genes is, and always has been, central to research on gene function. LÄS MER