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Visar resultat 1 - 5 av 8 avhandlingar som matchar ovanstående sökkriterier.
1. Molecular analysis of the FET family fusion oncoprotein FUS-DDIT3
Sammanfattning : Chromosomal translocations leading to formation of tumor type specific fusion oncogenes are frequently found in human cancers. The FET family genes (FUS, EWSR1 and TAF15) occur in translocations with genes encoding various transcription factors in sarcomas and leukemias. LÄS MER
2. Functional characterization of the liopsarcoma-associated fusion oncigene FUS-DDIT3
Sammanfattning : Fusion genes represent a growing class of translocation-derived potent oncogenes that frequently show tumor type-specific expression. We have studied the myxoid/round cell liposarcoma (MLS/RCLS)-specific FUS-DDIT3 fusion, with the aim of functionally characterizing this fusion oncogene in sarcoma development. LÄS MER
3. FET proteins in cancer and development
Sammanfattning : Chromosomal translocations leading to rearrangements of FET family genes (FUS, EWSR1 and TAF15) are found in numerous human cancers. These genetic alterations result in the formation of fusion oncogenes that express potent chimeric oncoproteins able to promote tumor development. LÄS MER
4. The role of fusion oncogenes and cancer stem cells in myxoid liposarcoma
Sammanfattning : Myxoid liposarcoma (MLS) is characterised by the FUS-DDIT3, or the less common EWSR1-DDIT3 fusion oncogene and is the second most common type of liposarcoma. The fusion oncogenes encode chimeric transcription factors that are causal factors in tumourigenesis however, their functions are poorly known. LÄS MER
5. Liposarcomas - proliferation, senescence and the role of DDIT3
Sammanfattning : Lipomatous tumors comprise benign and malignant forms called lipomas and liposarcomas. Myxoid/round cell liposarcoma (MLS/RCLS) is the second most common liposarcoma and is characterized by the fusion oncogenes FUS-DDIT3 or EWSR1-DDIT3. LÄS MER