Sökning: "FOLR1"

Hittade 3 avhandlingar innehållade ordet FOLR1.

  1. 1. Genetic variation in the folate receptor-alpha and methylenetetrahydrofolate reductase genes as determinants of plasma homocysteine concentrations

    Författare :Anna Böttiger; Torbjörn Nilsson; Henrik Zetterberg; Örebro universitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; Folate receptor-alpha; Folate; FOLR1; Haplotypes; Homocysteine; Methylenetetrahydrofolate reductase; MTHFR; Polymorphisms; Pyrosequencing®; SSCP; Medicine; Medicin; Biomedicin; Biomedicine;

    Sammanfattning : Elevated total plasma homocysteine (tHcy) is a risk factor for cardiovascular disease and neurocognitive disease such as dementia. The B vitamins folate and B12 are the main de terminants of tHcy. tHcy concentration can also be affected by mutations in genes coding for receptors, enzymes and transporters important in the metabolism of Hcy. LÄS MER

  3. 2. A fishing expedition for antidiabetic drugs : identifying new avenues to stimulate beta-cell regeneration

    Författare :Christos Karampelias; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : All types of diabetes are characterized by loss of the insulin-producing β-cells that reside in the pancreas. While current treatments can manage the disease, there is still no cure available. Understanding and promoting endogenous β-cell regeneration is an attractive approach that can lead to an eventual cure for diabetes. LÄS MER

  4. 3. DNA methylation in the placenta and in cancerwith special reference to folate transporting genes

    Författare :Sanja Farkas; Torbjörn Nilsson; Lars Breimer; Warren D. Kruger; Örebro universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DNA methylation; CRC; placenta; cervix; leukocytes; T-DMRs; folate; array; expression; Biomedicin; Biomedicine;

    Sammanfattning : DNA methylation is an epigenetic mechanism that regulates the gene transcription. Folate is used in cellular synthesis of methyl groups, nucleic acids and amino acids. In complex diseases like cancer and neural tube defects (NTD), various genetic and epigenetic alterations can be found that disrupt the normal cell function. LÄS MER