Sökning: "FHL-1"

Hittade 4 avhandlingar innehållade ordet FHL-1.

  1. 1. Mechanisms of phagocytosis resistance in Streptococcus pyogenes

    Författare :Heike Kotarsky; Lund Pediatrik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Microbiology; bacteriology; virology; mycology; Mikrobiologi; bakteriologi; virologi; mykologi; fibrinogen; FHL-1; Factor H; M protein; Streptococcus pyogenes; phagocytosis;

    Sammanfattning : A distinguishing feature of Streptococcus pyogenes (GAS) is their ability to resist phagocytosis in whole human blood in the absence of type-specific antibodies, a property that is dependent on the expression of the surface associated M proteins. A common characteristic of M proteins is their interaction with a variety of host proteins including the complement regulatory protein factor H (FH) and fibrinogen that plays a key role in coagulation. LÄS MER

  3. 2. Studies of bacterial surface proteins interacting with the immune system

    Författare :Henrik G Svensson; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bakteriologi; Mikrobiologi; virologi; mykologi; Microbiology; bacteriology; virology; mycology;

    Sammanfattning : Pathogenic bacteria express a wide array of surface proteins that interact with the environment. Many of these proteins are believed to be important for the virulence. This thesis deals with the binding of immunoglobulins (Ig) and complement regulating proteins to certain bacterial surface proteins. LÄS MER

  4. 3. Studies on streptococcal M proteins. Interactions with IgA and human complement regulators

    Författare :Eskil Johnsson; Institutionen för laboratoriemedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Microbiology; antigenic variation; factor H; C4b-binding protein; Fc-receptor; IgA; Streptococcus pyogenes; M protein; mykologi; virologi; bakteriologi; Mikrobiologi; virology; mycology; bacteriology;

    Sammanfattning : The human pathogenic bacterium Streptococcus pyogenes (group A Streptococcus) expresses several different virulence factors. Of these, the M protein is regarded as one of the most important, because it confers resistance to phagocytosis, allowing the bacterium to multiply in blood. LÄS MER

  5. 4. Interactions between Streptococcus pyogenes and the human immune defence

    Författare :Maria E Nilsson; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; M protein; Streptococcus pyogenes; Streptolysin O; The complement system; Neutrophils; Biomedical sciences; Biomedicinska vetenskaper; General biomedical sciences; Biomedicinska vetenskaper allmänt ; Microbiology; transplantation; Immunology; serology; mykologi; virologi; bakteriologi; Mikrobiologi; mycology; virology; Immunologi; serologi; Infections; Infektioner; Clinical biology; Klinisk biologi; bacteriology;

    Sammanfattning : Streptococcus pyogenes is an important human pathogen frequently colonizing the throat and skin of humans. To facilitate colonization and spread and to avoid the host immune defence, streptococci are endowed with a variety of virulence factors, two of which are investigated in this thesis namely streptolysin O (SLO) and M protein. LÄS MER