Sökning: "FGF-2"

Visar resultat 11 - 15 av 39 avhandlingar innehållade ordet FGF-2.

  1. 11. Heparan Sulfate Regulation of Fibroblast Growth Factor (FGF) Receptor-1 Signal Transduction

    Författare :Lars Lundin; Lena Claesson-Welsh; Marco Presta; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pathology; FGF; FGFR; dimerisation; signal transduction; heparan sulfate; proteoglycan; heparin; VEGF; embryonal stem cell; endothelial cell; differentiation; Patologi; Pathology; Patologi;

    Sammanfattning : Fibroblast growth factors (FGFs) constitute a family (currently FGF-1 to FGF-23) of polypeptides that are essential in embryonal development and adult physiology, in animals from nematodes to humans. FGFs bind to four receptor tyrosine kinases, denoted FGFR-1 to FGFR-4. LÄS MER

  3. 12. The role of VEGF family in angiogenesis, tumor growth and metastasis

    Författare :Xiaojuan Yang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Tumor growth is dependent on angiogenesis, and cells in tumor tissues produce various angiogenic factors to induce neovascularization. Among tumor-derived angiogenic factors, members of the vascular endothelial growth factor (VEGF) family are most frequently and highly expressed in various solid tumors. LÄS MER

  4. 13. Angiogenesis in childhood malignancies

    Författare :Erik Sköldenberg; Rolf Christofferson; Göran Läckgren; Agneta Nordenskjöld; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; Angiogenesis Factor; Biopsy; Needle; Neovascularization; Pathologic; Nephroblastoma; Reference value; Kirurgi; Surgery; Kirurgi; Pediatric Surgery; kirurgi; särskilt barnkirurgi;

    Sammanfattning : Angiogenesis is necessary for the growth and spread of solid tumors. In these studies angiogenesis was measured in childhood malignancies in general and in Wilms’ tumor in particular, and cutting needle biopsy (CNB) specimens were evaluated for diagnosis in childhood renal tumors. LÄS MER

  5. 14. Hem- and lymph-angiogenesis in cancer metastasis

    Författare :Hong Ji; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Angiogenesis, the process of sprouting new microvessels from the preexisting vasculature, is known to promote tumor growth. However, the role of tumor angiogenic vessels in facilitating metastasis remains poorly understood. LÄS MER

  7. 15. Molecular mechanisms of VEGF-mediated angiogenesis and vascular permeability

    Författare :Anna Eriksson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Angiogenesis; VEGF; vascular permeability;

    Sammanfattning : Angiogenesis, sprouting of new capillaries from pre-existing blood vessels, is a tightly regulated multi-step process. One of the key mediators in this process is the Vascular Endothelial Growth Factor (VEGF). Many tumors express high levels of VEGF and pathological angiogenesis is considered a hallmark of malignant tumor growth. LÄS MER