Sökning: "FA synthesis"

Visar resultat 1 - 5 av 18 avhandlingar innehållade orden FA synthesis.

  1. 1. AMP-activated protein kinase in adipose tissue

    Författare :Franziska Kopietz; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; AMPK; adipose tissue; adipocytes; diabetes; insulin; glucose uptake; lipolysis; FA synthesis; ADaM site activators;

    Sammanfattning : The AMP-activated protein kinase (AMPK) is a ubiquitously expressed kinase, which is activated in response to depletion of cellularenergy levels. Once active, it functions to alter cellular metabolism in a way that leads to restoration of energy levels. Therefore,AMPK is described as the key regulator of cellular energy homeostasis. LÄS MER

  3. 2. Insights Into Protein Synthesis - Structural Aspects of Elongation Factor G and Fusidic Acid Inhibition

    Författare :Sebastian Hansson; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molekylär biofysik; Structure chemistry; Strukturkemi; Molecular biophysics; Biologi; Biology; Biomedicinska vetenskaper; Biomedical sciences; conformational change; fusidic acid; protein synthesis; elongation factor G; crystal structures;

    Sammanfattning : Elongation factor G (EF-G) catalyses the translocation step in protein synthesis on the ribosome. During this event the antibiotic Fusidic acid (FA) binds to and irreversably inhibits the release of the EF-G:GDP complex from the ribosome. LÄS MER

  4. 3. Dynamics in Protein Synthesis, Structural Studies of Translation Factors

    Författare :Martin Laurberg; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biophysics; Flexibility; Fusidic Acid; tRNA; Translation Factors; Ribosome; Molekylär biofysik;

    Sammanfattning : Protein biosynthesis is performed on ribosomes. The ribosome is a complex of ribosomal RNA and proteins forming two subunits. A messenger RNA strand is decoded on the small subunit by charged aminoacyl transfer RNA (aa-tRNA) molecules and each tRNA molecule delivers its amino acid to the growing polypeptide chain on the large subunit. LÄS MER

  5. 4. Mechanisms and Inhibition of EF-G-dependent Translocation and Recycling of the Bacterial Ribosome

    Författare :Anneli Borg; Måns Ehrenberg; Ruben Gonzalez; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Protein synthesis; Elongation factor G; Translocation; Ribosome recycling; Fusidic acid; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

    Sammanfattning : The GTPase elongation factor G (EF-G) is an important player in the complex process of protein synthesis by bacterial ribosomes. Although extensively studied much remains to be learned about this fascinating protein. LÄS MER

  7. 5. Structural and Biochemical Studies of Antibiotic Resistance and Ribosomal Frameshifting

    Författare :Yang Chen; Maria Selmer; Dominique Fourmy; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; protein synthesis; elongation; elongation factor G; fusidic acid; antibiotic resistance; aminoglycoside adenyltransferase; ribosomal frameshifting; Biology with specialization in Structural Biology; Biologi med inriktning mot strukturbiologi;

    Sammanfattning : Protein synthesis, translation, performed by the ribosome, is a fundamental process of life and one of the main targets of antibacterial drugs. This thesis provides structural and biochemical understanding of three aspects of bacterial translation.Elongation factor G (EF-G) is the target for the antibiotic fusidic acid (FA). LÄS MER