Sökning: "Extracelular matrix"

Hittade 2 avhandlingar innehållade orden Extracelular matrix.

1. 1. Bone Enhancement with BMP-2 for Safe Clinical Translation

   Författare :Marta Kisiel; Jöns Hilborn; Monica Wiig; Richard Oreffo; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bone repair; Bone healing; Bone morhogenetic protein-2; Osteogenesis; Extracelular matrix; Hyaluronan; Animal model; Orthopaedics; Ortopedi; Engineering Science with specialization in Materials Science; Teknisk fysik med inriktning mot materialvetenskap;

   Sammanfattning : Bone morphogenetic protein-2 (BMP-2) is considered a promising adjuvant for the treatment of bone regeneration. However, BMP-2 delivery in a conventional collagen scaffold needs a high dose to achieve an effective outcome. Moreover, such dosage may lead to serious side effects. LÄS MER

3. 2. Human spinal cord models for development of spinal cord injury repair strategies

   Författare :Chenhong Lin; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : There is still no available cure for human spinal cord injury (SCI). After a SCI, neural cell loss, excitotoxicity, neuroinflammation, astrocytic and oligodendrocytic derived inhibiting factors contribute to a non-permissive spinal cord environment hindering neuroregeneration with little, if any, endogeneous functional improvement. LÄS MER