Sökning: "Extracellular pH"

Visar resultat 1 - 5 av 81 avhandlingar innehållade orden Extracellular pH.

  1. 1. Islet Transplantation a Technical Challenge : Studies on Human Pancreas Preservation and Enzymatic Digestion

    Författare :José Caballero-Corbalán; Olle Korsgren; Daniel Brandhorst; Ralf Segersvärd; Federico Bertuzzi; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Islet transplantation; Human islet isolation; Pancreas preservation; Two-layer method; Perfluorocarbon; Cold storage; Cold ischemia; University of Wisconsin solution; Histidine-tryptophan-ketoglutarate; HTK; Pancreas preservation; Prediction; Collagenase; Trasplante de islotes; Aislamiento de islotes; Preservación del pancreas; Método de las dos capas; Colagenasa; Solución de Wisconsin; HTK; Histidina-triptófano-ketoglutarato; Predicción; Endocrinology; Endokrinologi; Transplantation surgery; Transplantationskirurgi; Endokrinologi och Diabetologi; Endocrinology and Diabetology; Cellforskning; Cell Research; Klinisk immunologi; Clinical Immunology;

    Sammanfattning : Islet transplantation has found its niche in diabetes treatment. It has contributed to a better quality of life and better glycemic control of patients with diabetes suffering from severe hypoglycemia that are not eligible for vascularized pancreas transplantation. Islet isolation is a technically challenging procedure. LÄS MER

  3. 2. Recreating the microenvironment of the neurovascular unit

    Författare :Isabelle Matthiesen; Anna Herland; Thomas E. Winkler; Stéphanie Descroix; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; microphysiological systems; neurovascular unit; induced pluripotent stem cells; extracellular matrix; hydrogels; in vitro models; mikrofysiologiska system; neurovaskulära enheten; inducerade pluripotenta stamceller; extracellulära matrisen; hydrogeler; in vitro modeller; Bioteknologi; Biotechnology;

    Sammanfattning : The neurovascular unit (NVU) comprises the blood-brain-barrier (BBB) and its surrounding astrocytes, pericytes and neurons that are embedded in the extracellular matrix (ECM). As the main function of the BBB is to protect the brain from inlet of pathogens and toxins, the specialized endothelial cells that keep the barrier tight will also hinder the passage of pharmaceuticals. LÄS MER

  4. 3. Extracellular matrix mimetic multi-functional scaffolds for tissue engineering and biomedical applications

    Författare :Ranjithkumar Ravichandran; Jaywant Phopase; Anthony Turner; Ann-Christine Albertsson; Linköpings universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY;

    Sammanfattning : Regeneration of functional tissues or complex organs via the combination of viable cells, biomimetic scaffolds, morphogenic factors, and external biophysical cues are the principle aims of Tissue Engineering (TE). TE relies on the use of artificial 3D scaffolds that can mimic the microenvironment of native tissue to harness the regenerative potential of cells. LÄS MER

  5. 4. Regulation of Heparan Sulfate 6-O-Sulfation Patterns

    Författare :Anh-Tri Do; Marion Kusche-Gullberg; Ulf Lindahl; Malcolm Lyon; Uppsala universitet; []
    Nyckelord :Biochemistry; Heparan Sulfate; Biosynthesis; 6-O-sulfation; 6-O-sulfotransferases; 6-O-endosulfatases; Nematostella; Biokemi;

    Sammanfattning : Heparan sulfates (HSs) are linear, negatively charged polysaccharides composed of alternating hexuronic acid (glucuronic acid or iduronic acid) and glucosamine residues that can be substituted to varying degrees with sulfate groups. HS, localized in the extracellular matrix and on the surface of most cells, interacts with a large number of proteins. LÄS MER

  7. 5. Regulation of Fibroblast Activity by Keratinocytes

    Författare :Daniel Nowinski; Mikael Ivarsson; Bengt Gerdin; Elof Ph D M.D. Eriksson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; conective tissue growth factor; interleukin-1; fibroblast; keratinocyte; wound healing; burns; Kirurgi; Surgery; Kirurgi;

    Sammanfattning : In the healing of cutaneous wounds, paracrine communication between keratinocytes and fibroblasts regulates cell differentiation, proliferation and synthesis of extracellular matrix. Deficient epidermal coverage, as seen in burn-wounds, frequently results in hypertrophic scars. LÄS MER