Sökning: "Experimental autoimmune encephalomyelitis"

Visar resultat 1 - 5 av 73 avhandlingar innehållade orden Experimental autoimmune encephalomyelitis.

  1. 1. Immunogenetics and treatment of experimental autoimmune encephalomyelitis

    Författare :Robert Weissert; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Multiple sclerosis; experimental autoimmune encephalomyelitis; major histocompatibility complex; myelin; myelin oligodendrocyte glycoprotein; T cell receptor;

    Sammanfattning : Experimental autoimmune encephalomyelities (EAE) is a model of multiple sclerosis (MS). This experimental central nervous system (CNS) disease can be induced in rats by immunization with components of the CNS myelin sheath. LÄS MER

  3. 2. Suppressive DNA vaccination in experimental autoimmune encephalomyelitis

    Författare :Anna Lobell; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :DNA vaccination; autoimmunity; experimental autoimmune encephalomyelitis; multiple sclerosis; T cell receptor; CpG motif; myelin basic protein; myelin oligodendrocyte glycoprotein;

    Sammanfattning : This thesis describes the development of a novel method to suppress an organ-specific autoimmune disease, experimental autoimmune encephalomyelitis (EAE), by vaccination with DNA encoding autoantigenic peptides. DNA vaccination can produce long-term immunity and generate antigen-specific CD8+ and CD4+ T cells. LÄS MER

  4. 3. Initiation of Autoimmunity in Experimental Autoimmune Encephalomyelitis

    Författare :Magnus Isaksson; Anna Lobell; Olle Kämpe; William Agace; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Autoimmunity; Cytokines; Dendritic cells; DNA vaccination; EAE; Innate immunity; T helper cells; Toll-like receptors; Type I interferons; Molekylär medicin; Molecular Medicine;

    Sammanfattning : The events that trigger an autoimmune disease remain largely unknown. To study these events animal models are necessary because symptoms of autoimmune diseases are preceded by a long asymptomatic period in humans. LÄS MER

  5. 4. Studies of cellular pathogenesis in experimental autoimmune encephalomyelitis

    Författare :Judit Wefer; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :EAE; MS; autoimmunity; DNA vaccine; antigen-specific therapies;

    Sammanfattning : In this thesis, I have studied antigen-specific therapeutic interventions of experimental autoimmune encephalomyelitis (EAE) and aimed to understand the respective roles of different cell subsets in initiation and perpetuation of disease. EAE is a commonly used animal model for the human disease Multiple Sclerosis (MS), a demyelinating disease mainly affecting young adults. LÄS MER

  7. 5. Modulation of immune responses in experimental autoimmune encephalomyelitis

    Författare :Maja Wållberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MS; EAE; antigen-specific therapy; parasite; modified antigen;

    Sammanfattning : The aim of this thesis work has been to elucidate mechanisms for modulation of the immune response in experimental autoimmune encephalomyelitis (EAE), the animal model for the human disease multiple sclerosis (MS). MS is a degenerative disorder of the central nervous system (CNS) believed to be of autoimmune origin, meaning that components of the immune system attack the tissue in the CNS causing inflammation and destruction. LÄS MER