Sökning: "Exon"
Visar resultat 1 - 5 av 209 avhandlingar innehållade ordet Exon.
1. Genome and Transcriptome Comparisons between Human and Chimpanzee
Sammanfattning : The chimpanzee is humankind’s closest living relative and the two species diverged ~6 million years ago. Comparative studies of the human and chimpanzee genomes and transcriptomes are of great interest to understand the molecular mechanisms of speciation and the development of species-specific traits. LÄS MER
2. Mechanisms by which variants in the TCF7L2 gene increase the risk of developing Type 2 diabetes
Sammanfattning : Type 2 diabetes mellitus (T2DM) is a heterogeneous disease with a multifactorial aetiology comprising of genetic and environmental factors. The common variant most highly associated with T2DM known to date is a SNP rs7903146 in the TCF7L2 gene. However, the role TCF7L2 plays in the development of T2DM was unclear. LÄS MER
3. Regulation of neurotrophins and their receptors : molecular aspects and functional implications
Sammanfattning : The aim of this work was to study the regulation of neurotrophins and their receptors in a functional aspect. The studies included analysis of neuronal and glial neurotrophin gene expression, that was investigated by using molecular biological techniques. LÄS MER
4. Hormone-sensitive lipase: Molecular analyses of the human gene; structural and evolutionary aspects on expression, alternative splicing and cold adaptation
Sammanfattning : Hormone-sensitive lipase (HSL) is a key enzyme in adipose tissue that hydrolyses stored fat (triacylglycerol). The activity of HSL is under strict hormonal and neural control. LÄS MER
5. The immunoglobulin genes in an Actinopterygian fish, the Siberian sturgeon (Acipenser baeri)
Sammanfattning : Characterization of the immunoglobulin (Ig) light (L) and heavy (H) chain genes from the Siberiansturgeon, Acipenser baeri, revealed an Ig structure simhar to the IgM elass of mammals. The serumforms of the sturgeon Ig are tetrameric and dimeric. LÄS MER