Sökning: "Estrogen Receptor ?"

Visar resultat 1 - 5 av 229 avhandlingar innehållade orden Estrogen Receptor ?.

  1. 1. G protein-coupled receptor regulation: The role of protein interactions and receptor trafficking

    Författare :Caroline Sandén; Drug Target Discovery; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; receptor trafficking; B1 receptor; receptor oligomerization; estrogen; GPER1; G protein-coupled estrogen receptor 1; EP24.15; BK; bradykinin; B1R; B2R; B2 receptor; GPCR; receptor maturation;

    Sammanfattning : The superfamily of G protein-coupled receptors (GPCR) is the largest gene family in the human genome. GPCR-mediated signaling operates in every human cell, and about 50% of existing clinically useful drugs act through GPCR. LÄS MER

  3. 2. Expression and function of vascular estrogen receptors alpha and beta

    Författare :Min Liang; Kärlfysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endocrinology; secreting systems; diabetologi; diabetology; Endokrinologi; sekretion; ubiquitin-proteasome pathway; MIP-2; MCP-1; iNOS; estrogen receptor knockout; estrogen receptor; aorta; estrogen;

    Sammanfattning : Estrogen receptors (ER) are expressed not only in classical target organs for estrogen like breast and uterus, but also in male reproductive system as well as in non-reproductive organs such as brain, liver and bone. The functions of ER are quite well known in reproductive organs but less information is available regarding their function in vascular tissue. LÄS MER

  4. 3. Immunomodulation by estrogen and estren

    Författare :Ulrika Islander; Göteborgs universitet; []
    Nyckelord :estrogen receptor knock-out mice; estrogen; estren; estrogen receptor; lymphopoiesis; T cells; B cells; immunoglobulin; inflammation;

    Sammanfattning : Estrogen affects the development and regulation of the immune system. Treatment of gonadectomized mice with estrogen results in suppression of T and B lymphopoiesis, as well as decreased delayed type hypersensitivity reaction, granulocyte mediated inflammation and levels of IL-6 in serum. LÄS MER

  5. 4. Estrogen and Glucocorticoid Metabolism

    Författare :Therése Andersson; Tommy Olsson; Cecilia Mattsson; Ingegerd Söderström; Jonas Burén; Agneta Holmäng; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; 11β-Hydroxysteroid Dehydrogenase Type 1; Estrogen; Cortisol; Adipose tissue; Liver; Menopause; Ovariectomy; Adipocyte; Estrogen Receptor β; Endocrinology; Endokrinologi; medicin; Medicine;

    Sammanfattning : Background: Cardiovascular disease (CVD) is the leading cause of death among women in Sweden. The risk of CVD increases rapidly after the menopause. A major contributing factor may be the redistribution of adipose tissue, from the peripheral to central depots, associated with menopause. LÄS MER

  7. 5. Stroke, Sex and Vascular Receptor Changes in the Brain

    Författare :Hilda Ahnstedt; Lund Medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; endothelin receptors; Cerebral ischemia; sex; estrogen; progesterone; sex differences; human cerebral arteries; endothelin-1; angiotensin II; middle cerebral artery occlusion; extra-cellular signal regulated kinase 1 and 2;

    Sammanfattning : Stroke is a severe cerebrovascular disease in which the neuronal tissue and vasculature of the brain undergo ischemia-evoked alterations. We have demonstrated an increased expression of cerebrovascular contractile receptors in the brain. This is hypothesized to mitigate cerebral blood flow and exacerbate tissue damage after stroke. LÄS MER