Sökning: "Esophageal cancer"

Visar resultat 1 - 5 av 46 avhandlingar innehållade orden Esophageal cancer.

  1. 1. Genomic Profiling, Mutations and Deranged Signaling in Esophageal Cancer and Hereditary Colorectal Cancer

    Detta är en avhandling från Lund University: Faculty of Medicine

    Författare :Anna Isinger Ekstrand; [2010]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Esophageal cancer; hereditary cancer; HNPCC; copy number analysis; CGH; gene expression; Wnt; PIK3CA; CHEK2; gastric cancer; colorectal cancer;

    Sammanfattning : Esophageal cancer and colorectal cancer represents two major types of gastrointestinal tumors. Though refined surgery and introduction of novel chemotherapeutics have improved outcome, more than 2500 Swedes die from these diseases every year. Novel markers for early diagnosis, prognosis and treatment prediction are therefore needed. LÄS MER

  2. 2. Esophageal- and Gastroesophageal Junctional Cancer Aspects on Staging, Treatment and Results

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Gustav Linder; Jakob Hedberg; Magnus Sundbom; Wilhelm Graf; Bas P.L. Wijnhoven; [2018]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Esophageal cancer; Education level; Tonometry; Lymphadenectomy; PET MRI; Kirurgi; Surgery;

    Sammanfattning : Esophageal- and gastroesophageal junctional (GEJ) cancer is the sixth cause of cancer-related death worldwide. Some improvements in care are attributed to nationwide disease-specific registries, preoperative staging and increased understanding of mechanisms affecting patient selection. LÄS MER

  3. 3. Pathophysiology of 5-fluorouracil induced cardiotoxicity : a clinical and experimental study

    Detta är en avhandling från Magdalena Cwikiel, Dep of Oncology, University Hospital, 221 85 LUND, Sweden

    Författare :Magdalena Cwikiel; [1996]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oncology; Cytology; cell culture.; scanning and transmission electron microscopy; endothelium; lipid peroxidation; free radical; fibrinogen; 5-fluorouracil; blood and plasma viscosity; cardiotoxicity; cancerology; Cytologi; onkologi; cancer; Pharmacological sciences; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

    Sammanfattning : This thesis concerns the pathophysiology of 5-fluorouracil (5-FU) induced cardiotoxicity. The aim of the clinical studies was to determine whether hemorheological factors might explain 5-FU cardiotoxicity (I) and if the syndrome was associated with free radical (FR) generation and lipid peroxidation (II). LÄS MER

  4. 4. Dietary phytoestrogens and esophageal cancer

    Detta är en avhandling från Stockholm : Karolinska Institutet, Dept of Molecular Medicine and Surgery

    Författare :Yulan Lin; Karolinska Institutet.; Karolinska Institutet.; [2013]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Esophageal cancer is the eighth most common invasive cancer in the world, a cancer with an increasing incidence and male predominance, and there is a great need for potential dietary prevention. The overall aim of this thesis was to evaluate whether the dietary phytoestrogens lignans might play a protective role in the etiology of esophageal cancer, including gastroesophageal junctional adenocarcinoma. LÄS MER

  5. 5. Towards improved oncological treatment of esophageal and gastric cancer. Clinical and translational studies

    Detta är en avhandling från Lund University, Faculty of Medicine

    Författare :David Borg; [2019]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Esophageal adenocarcinoma; Gastric cancer; PODXL; Prognosis; Prediction; Chemotherapy dose intensity; Dysphagia; Radiotherapy;

    Sammanfattning : BackgroundThe overall aim of this thesis was to improve the oncological treatment strategies in esophageal and gastric adenocarcinoma (EGAC). Podocalyxin-like protein 1 (PODXL) has been associated with poor prognosis in other cancers and we wanted to investigate its potential role as a prognostic and predictive biomarker in resectable EGAC. LÄS MER