Sökning: "Escherichia coli toxins"

Visar resultat 1 - 5 av 18 avhandlingar innehållade orden Escherichia coli toxins.

1. 1. Structural analyses of carbohydrate receptors for enterotoxins and adhesins of enterotoxigenic Escherichia coli

   Författare :Dani Zalem; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Carbohydrate recognition; glycosphingolipid; diarrheagenic E. coli; ETEC; heat-labile enterotoxin; colonization factor; AB5 toxins;

   Sammanfattning : Carbohydrate-binding proteins expressed by microbes are key determinants in initiating and sustaining infections that account for millions of deaths each year. This thesis fo- cused on proteins integral to infections instigated by enterotoxigenic Escherichia coli (ETEC); estimated as the largest bacterial cause of diarrhea in the world with hundreds of millions of cases each year. LÄS MER

3. 2. Regulatory mechanisms involved in pathoadaptation of extraintestinal pathogenic Escherichia coli

   Författare :Nikola Zlatkov; Bernt Eric Uhlin; Åke Forsberg; Sun Nyunt Wai; Eliora Ron; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ExPEC; PAIs; pathoadaptation; citrate; metabolism; filamentation; toxins; molekylärbiologi; Molecular Biology; mikrobiologi; Microbiology;

   Sammanfattning : Establishment of commensal bacteria within a new niche of their host usually promotes the transition from commensalism to pathogenicity. Extraintestinal Pathogenic Escherichia coli (ExPEC) represent different pathovars with biphasic lifestyle – they can reside in the gut as commensals or they can escape and cause diseases elsewhere in the human body. LÄS MER

4. 3. Studies of pore-forming bacterial protein toxins in Escherichia coli

   Författare :Constance Enow; Bernt Eric Uhlin; Sun Nyunt Wai; Mikael Rehn; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; molekylärbiologi; Molecular Biology;

   Sammanfattning : Escherichia coli, a Gram-negative bacterium, which can be classified into three groups: the commensal, intestinal pathogenic (IPEC) and extra-intestinal pathogenic (ExPEC) E. coli. The cytolysin A (ClyA) protein, a 34-kDa pore-forming toxin, encoded by a gene found in both non-pathogenic and pathogenic E. LÄS MER

5. 4. Whole Genome Sequencing of Enterotoxigenic Escherichia coli

   Författare :Astrid von Mentzer; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; ETEC; whole genome sequencing; evolution; colonization factor; reverse genetics;

   Sammanfattning : Enterotoxigenic Escherichia coli (ETEC) infections are a common cause of diarrhea but little is known about the evolution and genomic composition of ETEC. The main aim of this thesis was to generate a large collection of whole genome sequenced ETEC isolates to study the evolution of such bacteria on a global level and to search for novel colonization factors (CFs) using both classical and cutting-edge genomic techniques. LÄS MER

7. 5. Virulence factors and clonal relatedness of enterotoxigenic Escherichia coli (ETEC) isolated from children with diarrhoea in Bolivia

   Författare :Claudia Rodas Miranda; Göteborgs universitet; []
   Nyckelord :Enterotoxigenic Escherichia coli; Virulence factors; Bolivia; Children; Severity of disease; Relatedness;

   Sammanfattning : Enterotoxigenic Escherichia coli (ETEC) is one of the major causes of diarrhoea in children under five years of age in developing countries and in travellers to these settings. To cause disease, ETEC must be able to colonize the small intestine and produce heat-stable enterotoxin (ST) or heat-labile toxin (LT) or both toxins. LÄS MER