Sökning: "Erk1 2"

Visar resultat 6 - 10 av 103 avhandlingar innehållade orden Erk1 2.

  1. 6. Prognostic role of tumour associated trypsin inhibitor in colorectal cancer patients

    Författare :Alexander Gaber; Tumörmikromiljö; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; KRAS mutation; ERK1 2; TATI; Colorectal cancer; Prognosis; Biomarker; EGFR; STAT3;

    Sammanfattning : Colorectal cancer (CRC) is one of the most common forms of human cancer worldwide with approximately 1 million new cases detected every year. CEA is currently the only accepted CRC marker incorporated into clinical practice, where it is used for early detection of metastasis in follow-up of patients having stage II and III disease, and for monitoring response to adjuvant treatment. LÄS MER

  3. 7. Novel strategies to improve thrombolysis therapy after stroke

    Författare :Kajsa Arkelius; Neurokirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ischemic stroke; thrombolysis; rt-PA; MMP-9; ERK1 2; LOX-1; BBB;

    Sammanfattning : .... LÄS MER

  4. 8. Modulation of the Progenitor Cell and Homeostatic Capacities of Müller Glia Cells in Retina : Focus on α2-Adrenergic and Endothelin Receptor Signaling Systems

    Författare :Mohammad Harun-Or-Rashid; Finn Hallböök; Per Ekström; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alpha2-adrenergic receptor; Brimonidine; Brn3a; Dedifferentiation; Endothelin; EGFR; ERK1 2; Neuroprotection; NMDA; MIO-M1 human Müller cell; Müller cells; Retina; Retinal ganglion cells; Src-kinase; Transactivation.; Medical Science; Medicinsk vetenskap;

    Sammanfattning : Müller cells are major glial cells in the retina and have a broad range of functions that are vital for the retinal neurons. During retinal injury gliotic response either leads to Müller cell dedifferentiation and formation of a retinal progenitor or to maintenance of mature Müller cell functions. LÄS MER

  5. 9. Notch Signaling in Human Neuroblastoma Cells

    Författare :Marie Stockhausen; Institutionen för translationell medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oncology; Hes-1; Medicin människa och djur ; Medicine human and vertebrates ; hypoxia; TGF-alpha; EGFR; ERK1 2; Ras MAPK; differentiation; valproic acid; ubiquilin-1; neuroblastoma; Hash-1; Cytologi; onkologi; cancer; cancerology; Cytology; Notch;

    Sammanfattning : Neuroblastoma is a childhood tumor derived from the sympathetic nervous system (SNS). It is believed that the tumors arise from cells halted in their differentiation and due to their immature phenotype; they express proteins normally only detected during embryogenesis. One such protein is Hash-1, which is required for formation of the SNS. LÄS MER

  7. 10. A Path for Improving Stroke Recovery. Effects of MEK-ERK1/2 Inhibition

    Författare :Maryam Mostajeran; Lund Medicin; []
    Nyckelord :Ischemic stroke; Extracellular-signal regulated kinase ERK 1 2; Mitogen activated protein kinase kinase MEK 1 2; Recovery; Functional outcome; sex;

    Sammanfattning : The present thesis aimed to shed more light on the notion of acute inhibition of extracellular-signal regulated kinase (ERK)1/2 pathway as a treatment to improve stroke recovery. Stroke is a major cause of death and long-term disability worldwide, classified as ischemic or hemorrhagic. LÄS MER