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1. 1. De oraculis Græcis dissertatio quam venia ampl. facult philos. Upsal. p. p. mag. Gustavus O. Sjögren ... et Ericus Magnus Holmgren stipendiarius regius. Vestrogothi. in audit. Gustaviano die X Maji MDCCCXV h. p. m. s. P. II

   Författare :Gustav Olof Sjögren; Erik Magnus Holmgren; Gustav Olof Sjögren; Uppsala universitet; []
   Nyckelord :HUMANIORA; HUMANITIES;

   Sammanfattning : .... LÄS MER

3. 2. Epilithische und epigäische Moosvegetation in Laubwäldern der Insel Öland (Schweden)

   Författare :Erik Sjögren; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Mosses; Mossor;

   Sammanfattning : .... LÄS MER

4. 3. Hepatic Disposition of Drugs and the Utility of Mechanistic Modelling and Simulation

   Författare :Erik Sjögren; Hans Lennernäs; Scott Obach; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hepatic disposition; pharmacokinetics; mechanistic modelling; drug-drug interactions; enzyme kinetics; Vmax; Km; CLint; carrier-mediated transport; active transport; modelling; in vitro-in vivo extrapolation; physiologically based pharmacokinetic model; optimal experimental design; experimental optimization; data analysis optimization; PHARMACY; FARMACI; Biopharmacy; Biofarmaci; Biopharmaceutics; Biofarmaci;

   Sammanfattning : The elimination of drugs from the body is in many cases performed by the liver. Much could be gained if an accurate prediction of this process could be made early in the development of new drugs. However, for the elimination to occur, the drug molecule needs first to get inside the liver cell. LÄS MER

5. 4. In vitro evaluation of formulations used in the treatment of hepatocellular carcinoma

   Författare :Emelie Ahnfelt; Hans Lennernäs; Erik Sjögren; Niklas Axén; Jesper Østergaard; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Drug delivery system; Doxorubicin; Microgel; Emulsion; Hepatocellular carcinoma; Biofarmaci; Biopharmaceutics;

   Sammanfattning : Hepatocellular carcinoma (HCC) causes ~ 600,000 deaths annually, making it the second most deadly cancer form. HCC is classified into five stages and for the intermediate HCC treatment, the two most commonly used drug delivery systems (DDSs) are lipiodol-based emulsions and drug-eluting beads. LÄS MER

7. 5. Biopharmaceutical aspects of intestinal drug absorption : Regional permeability and absorption-modifying excipients

   Författare :David Dahlgren; Hans Lennernäs; Erik Sjögren; Bertil Abrahamsson; Christer Tannergren; Steffansen Bente; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; intestinal permeability; absorption-modifying excipients; Biofarmaci; Biopharmaceutics;

   Sammanfattning : Before an orally administered drug reaches the systemic circulation, it has to dissolve in the intestinal fluids, permeate across the intestinal epithelial cell barrier, and pass through the liver. The permeation rate of drug compounds can be low and show regional differences.The thesis had two general aims. LÄS MER