Sökning: "Erik Lindahl"

Visar resultat 21 - 25 av 40 avhandlingar innehållade orden Erik Lindahl.

1. 21. Peering Beyond the Noise in Experimental Biophysical Data

   Författare :Dari Kimanius; Erik Lindahl; Holger Stark; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cryo-EM; mitochondrial ribosome; SAXS; molecular dynamics; metadynamics; Biochemistry towards Bioinformatics; biokemi med inriktning mot bioinformatik;

   Sammanfattning : Experimental protein structure determination methods make up a fundamental part of our understanding of biological systems. Manual interpretation of the output from these methods has been made obsolete by the sheer size and complexity of the acquired data. LÄS MER

3. 22. Prediction, modeling, and refinement of protein structure

   Författare :Per Larsson; Arne Elofsson; Erik Lindahl; Barry Honig; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Protein structure prediction; Multiple alignments; Quality assessment; Molecular dynamics; Implicit solvent; Refinement; Bioinformatics; Bioinformatik; Bioinformatics; Bioinformatik; Statistical mechanics; Statistisk mekanik; Biochemistry; biokemi;

   Sammanfattning : Accurate predictions of protein structure are important for understanding many processes in cells. The interactions that govern protein folding and structure are complex, and still far from completely understood. However, progress is being made in many areas. Here, efforts to improve the overall quality of protein structure models are described. LÄS MER

4. 23. Combining low resolution, high resolution, functional, and simulation techniques : In the study of pentameric ligand-gated ion channels

   Författare :Marie Lycksell; Erik Lindahl; Kresten Lindorff-Larsen; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Neutrons; Small-angle scattering; Cryo-EM; Simulations; Ion channels; Biophysics; biofysik;

   Sammanfattning : Combining methods yielding different information is a powerful approach for understanding structural biology in general, and in particular systems such as pentameric ligand-gated ion channels (pLGICs). Pentameric ligand-gated ion channels are membrane proteins that sense chemical signals, which they convert to changes in membrane potential. LÄS MER

5. 24. From Sequence to Structure : Using predicted residue contacts to facilitate template-free protein structure prediction

   Författare :Mirco Michel; Arne Elofsson; Erik Lindahl; Johannes Söding; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; protein bioinformatics; protein structure prediction; contact prediction; machine learning; Biochemistry towards Bioinformatics; biokemi med inriktning mot bioinformatik;

   Sammanfattning : Despite the fundamental role of experimental protein structure determination, computational methods are of essential importance to bridge the ever growing gap between available protein sequence and structure data. Common structure prediction methods rely on experimental data, which is not available for about half of the known protein families. LÄS MER

7. 25. Quality assessment of protein models

   Författare :Arjun Ray; Erik Lindahl; Bengt Persson; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; SRA - Molecular Bioscience; SRA - Molekylär biovetenskap;

   Sammanfattning : Proteins are crucial for all living organisms and they are involved in many different processes. The function of a protein is tightly coupled to its structure, yet to determine the structure experimentally is both non-trivial and expensive. LÄS MER