Sökning: "Epithelial barrier function"

Visar resultat 16 - 20 av 72 avhandlingar innehållade orden Epithelial barrier function.

  1. 16. Mechanisms of bacterial-epithelial interaction in Crohn’s disease

    Författare :Ida Schoultz; Johan D. Söderholm; Nicola Jones; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Crohn’s disease (CD) is believed to be initiated when an individual, who has agenetic predisposition either leading to a disturbance in the barrier functionand/or the innate immune system is exposed to triggering environmentalfactors, the most important being intraluminal bacteria. Genetic and functionalstudies have confirmed the Pattern-recognition receptors (PRRs), Nod2, TLR4and NALP3, as important mediators of the inflammatory process associatedwith disease progression. LÄS MER

  3. 17. The human antimicrobial peptide hCAP18 in epithelial defense

    Författare :Margareta Frohm Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Innate immunity; host defense; antimicrobial peptide; hCAP 18; LL-37; epithelia; wounds; breast cancer;

    Sammanfattning : Gene-encoded antimicrobial peptides serve a protective role in host defense. They are multifunctional effector molecules in innate immunity - the nonadaptive immune system -with the capacity to kill a broad spectrum of microorganisms. LÄS MER

  4. 18. Molecular biosignatures and gut-barrier alterations in inflammatory bowel diseases

    Författare :Luiza Moraes Holst; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Inflammatory bowel diseases; ulcerative colitis; Crohn s disease; IBD; immunopathogenesis;

    Sammanfattning : Inflammatory bowel diseases (IBD) are chronic immune-mediated disorders affecting the gastrointestinal tract. The multifactorial pathophysiology of IBD is commonly explained as an abnormal interplay between genetic, immune, environmental and microbial factors. LÄS MER

  5. 19. Regulation of E-cadherin mediated adhesion in thyroid epithelial cells

    Författare :Fredrik Larsson; Göteborgs universitet; []
    Nyckelord :thyroid; adherens junction; E-cadherin; thyrotropin; cAMP; PKA; Epac; IQGAP;

    Sammanfattning : Cell adhesion is one of multicellular organisms most fundamental features. Cells connect to each other by transmembrane proteins arranged in junction complexes. LÄS MER

  7. 20. Grainy head target genes in epithelial morphogenesis and wound healing

    Författare :Shenqiu Wang; Christos Samakovlis; Paul Martin; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; grh; targets; epidermal wound repair; tracheal tube size control; local immune responses; stit; verm; serp; PGRP-LC; CecA-LacZ; Developmental biology; Utvecklingsbiologi; utvecklingsbiologi; Developmental Biology;

    Sammanfattning : grainy head (grh) genes encode a family of transcription factors conserved from fly to human. Drosophila grh is the founding member of this gene family and has multiple functions, including tracheal tube size control, epidermal barrier formation and reconstruction after wounding. LÄS MER