Sökning: "Eosinofiler astma"
Hittade 3 avhandlingar innehållade orden Eosinofiler astma.
1. Development and Resolution of Allergic Airway Inflammation in vivo: effects of therapeutic interventionDetta är en avhandling från Department of Experimental Medical Science, Lund Univeristy
Sammanfattning : Eosinophils, containing tissue toxic granule proteins, are regarded a culprit cell in asthma pathogenesis. Using animal and human experimental models of asthma effects on eosinophilic airway inflammation were investigated in vivo. LÄS MER
- Detta är en avhandling från Department of Laboratory Medicine, Lund University
Sammanfattning : In allergic disorders, the eosinophilic granulocytes migrate to affected tissues and release granule proteins with cytotoxic, immunoregulatory, and remodeling-promoting properties. Given that degranulation is reflected by a loss in eosinophil granule density of living cells, or by cell membrane rupture and release of intact granules, these morphological changes may represent a biomarker of the allergic disease. LÄS MER
3. Glucocorticosteroid effects on cytokine production: studies in a glucocorticosteroid resistance model and in allergic airway diseaseDetta är en avhandling från Department of Respiratory Medicine and Allergology, Lund University
Sammanfattning : Glucocorticosteroids (GCS) are potent anti-inflammatory drugs, probably due to inhibitory effects on cytokine production. However, a small number of asthma patients seem GCS-resistant. Pro-inflammatory cytokines, such as interleukin-2(IL-2) and IL-4, produced during allergic airway inflammation have been proposed to induce the resistance to GCS. LÄS MER