Sökning: "Eosinofiler astma"

Hittade 3 avhandlingar innehållade orden Eosinofiler astma.

  1. 1. Development and Resolution of Allergic Airway Inflammation in vivo: effects of therapeutic intervention

    Detta är en avhandling från Department of Experimental Medical Science, Lund Univeristy

    Författare :Lena Uller; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2005]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Andningsorganen; Respiratory system; Medicin människa och djur ; Medicine human and vertebrates ; Animal models; Glucocorticoids; Eosinophils; Apoptosis; Asthma; Allergy;

    Sammanfattning : Eosinophils, containing tissue toxic granule proteins, are regarded a culprit cell in asthma pathogenesis. Using animal and human experimental models of asthma effects on eosinophilic airway inflammation were investigated in vivo. LÄS MER

  2. 2. Assessment of eosinophil degranulation in allergic diseases and experimental models

    Detta är en avhandling från Department of Laboratory Medicine, Lund University

    Författare :Monika Malm-Erjefält; Lund University.; Lunds universitet.; [2004]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; blood; histochemistry; cytochemistry; tissue culture; Histologi; cytokemi; histokemi; vävnadskultur; animal morphology; Animal anatomy; Djurs anatomi och morfologi; Haematology; cytoplasmic granules ; Hematologi; Respiratory system; extracellulära vätskor; Andningsorganen; toxikologi; farmaci; farmakognosi; Farmakologi; toxicology; pharmacy; pharmacognosy; Klinisk biologi; Pharmacological sciences; Histology; cell separation ; mice; animal models ; biological marker ; transmission electron microscopy allergy; cell degranulation ; Clinical biology; extracellular fluids; eosinophils;

    Sammanfattning : In allergic disorders, the eosinophilic granulocytes migrate to affected tissues and release granule proteins with cytotoxic, immunoregulatory, and remodeling-promoting properties. Given that degranulation is reflected by a loss in eosinophil granule density of living cells, or by cell membrane rupture and release of intact granules, these morphological changes may represent a biomarker of the allergic disease. LÄS MER

  3. 3. Glucocorticosteroid effects on cytokine production: studies in a glucocorticosteroid resistance model and in allergic airway disease

    Detta är en avhandling från Department of Respiratory Medicine and Allergology, Lund University

    Författare :Susanne Larsson; Lund University.; Lunds universitet.; [2000]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; GM-CSF; cytokine; glucocorticoids; budesonide; IL-2; IL-4; IL-12; asthma; allergic rhinitis; allergic airway inflammation; Respiratory system; Andningsorganen;

    Sammanfattning : Glucocorticosteroids (GCS) are potent anti-inflammatory drugs, probably due to inhibitory effects on cytokine production. However, a small number of asthma patients seem GCS-resistant. Pro-inflammatory cytokines, such as interleukin-2(IL-2) and IL-4, produced during allergic airway inflammation have been proposed to induce the resistance to GCS. LÄS MER